17 results
Primary: To further characterize a cohort of older patients with bipolar disorder, including clinical features, cognition, social functioning, need of care, family history and inflammation markers.Secondary: To investigate the effects of aging on…
Little research is being done on the effects of psychological treatment in patients with a bipolar disorder (BD) and comorbide borderline personality disorder (BPD) features. There are no recommendations included in the guideline for BD (Nolen et al…
Primary objective: Are changes in stress-induced autonomic and hormonal parameters associated with (epi)genetic vulnerability for schizophrenia and bipolar disorder?Secondary objectives: 1. Are changes in autonomic and hormonal parameters after…
The objective of this study is to include 200 cases, 200 unaffected first and second degree family members and 200 unrelated healthy controls to participate in the assessment of variability in activity and light exposure, as these domains are…
The main goal of this study is to recruit and obtain magnetic resonance images in a large sample of bipolar patients and controls from the Netherlands, in order to find brain abnormalities specific for bipolar disorder. We will also perform genetic…
Primary objective: To investigate whether sleep disturbances during pregnancy and/or in the perinatal period will predict postpartum psychopathology in women with an established diagnosis of bipolar disorder and/or a history of postpartum psychosis.…
To evaluate two biomarker tests (characterized by an activated inflammatory response system (IRS) as reflected by an aberrant monocyte gene expression signature and/or a disturbed metabolism of tryptophan) by comparing patients with BD with healthy…
Study A: Show BP patients similar progression in brain volume change compared to schizophrenia patients. If so, can the progressive change in BP patients also be explained by genetic factors?Study B: Show BP patients and their non-bipolar cotwins…
1. Define risk profiles based on retrospective data in a cohort of bipolar patients. These profiles will be based on the effects of various combinations of MR and GR genotypes involved in stress regulation on symptoms, course of the illness and…
The objective of the study is to investigate the long-termeffects of lithium on the development of children who are exposed to lithium during pregnancy.
The objective of the current study is to investigate the feasibility of a within subject longitudinal design to investigate the relationship between cognition, mood, clinical factors and other psychosocial variables that may be of influence in…
The main objective is to define the self-test performance by means of the Total Error for the Medimate Minilab 2017 for the set of parameters.
Primary Objective: To identify immuno-endocrine and neuro-imaging parameters differentiating between different mood states (manic, depressive, and euthymic). Secondary Objectives: 1. To identify the influence of these parameters on the onset and…
To provide insights into 1) the risk to develop BD and other psychiatric disorders after age 30, and 2) explore functional outcome at adult age and study the link between (early)psychiatric outcome and functional outcome. Moreover, compare the…
The primary objective is the extent and kind of cognitive deficits in patients suffering from bipolar disorders compared to healthy controls and patients with a lifetime diagnosis of unipolar depressive disorder. Secondary objectives specify the…
Primary:- Investigate the feasibility of examining fetal and neonatal brain developmental trajectories in the fetus and neonate with at least one parent with SMI in the mood-psychosis spectrum (vs. parents without SMI) using MRI.- Acquire…
The primary aim of this study is to investigate if prophylactic pharmacotherapy peripartum is associated with a lower chance of relapse peripartum. In more detail, we will investigate if there is a difference in relapse between patients that used…