12 results
Primary: To further characterize a cohort of older patients with bipolar disorder, including clinical features, cognition, social functioning, need of care, family history and inflammation markers.Secondary: To investigate the effects of aging on…
Primary objective: Are changes in stress-induced autonomic and hormonal parameters associated with (epi)genetic vulnerability for schizophrenia and bipolar disorder?Secondary objectives: 1. Are changes in autonomic and hormonal parameters after…
The objective of this study is to include 200 cases, 200 unaffected first and second degree family members and 200 unrelated healthy controls to participate in the assessment of variability in activity and light exposure, as these domains are…
The main goal of this study is to recruit and obtain magnetic resonance images in a large sample of bipolar patients and controls from the Netherlands, in order to find brain abnormalities specific for bipolar disorder. We will also perform genetic…
Study A: Show BP patients similar progression in brain volume change compared to schizophrenia patients. If so, can the progressive change in BP patients also be explained by genetic factors?Study B: Show BP patients and their non-bipolar cotwins…
1. Define risk profiles based on retrospective data in a cohort of bipolar patients. These profiles will be based on the effects of various combinations of MR and GR genotypes involved in stress regulation on symptoms, course of the illness and…
The objective of the study is to investigate the long-termeffects of lithium on the development of children who are exposed to lithium during pregnancy.
The objective of the current study is to investigate the feasibility of a within subject longitudinal design to investigate the relationship between cognition, mood, clinical factors and other psychosocial variables that may be of influence in…
Primary Objective: To identify immuno-endocrine and neuro-imaging parameters differentiating between different mood states (manic, depressive, and euthymic). Secondary Objectives: 1. To identify the influence of these parameters on the onset and…
The primary objective is the extent and kind of cognitive deficits in patients suffering from bipolar disorders compared to healthy controls and patients with a lifetime diagnosis of unipolar depressive disorder. Secondary objectives specify the…
Primary:- Investigate the feasibility of examining fetal and neonatal brain developmental trajectories in the fetus and neonate with at least one parent with SMI in the mood-psychosis spectrum (vs. parents without SMI) using MRI.- Acquire…
The primary aim of this study is to investigate if prophylactic pharmacotherapy peripartum is associated with a lower chance of relapse peripartum. In more detail, we will investigate if there is a difference in relapse between patients that used…