Search for a trial

CONgenital Cytomegalovirus: Efficacy of antiviral treatment in a non-Randomized Trial with historical control group

Primary Objective: Investigate whether early valganciclovir treatment of children with SNHL of * 20 dB, unilateral or bilateral, and a confirmed congenital CMV infection can prevent deterioration of the hearing loss at follow-up (age 18 * 22 months…

Bumetanide in Autism Medication and Biomarker study

The primary objective of the proposed study is to investigate whether bumetanide therapy indeed reduces autistic symptomatology. Important secondary goals of this project are to determine whether bumetanide will improve specific behavioral,…

*Working memory training in children with neuropsychiatric disorders and borderline intellectual functioning*

1. To investigate the efficacy of Cogmed working memory training in reducing behavioral symptoms in children with neuropsychiatric disorders and borderline intellectual functioning.2. To investigate whether WM training improves neurocognitive…

The CONCERT study
CONgenital Cmv: Efficacy of antiviral treatment in a Randomized controlled Trial

Primary Objective: Investigate whether early valganciclovir treatment of children with SNHL of >= 20 dB, unilateral or bilateral, and a confirmed congenital CMV infection can prevent deterioration of the hearing loss at 1 year follow-up.…

An exploratory study on the effectiveness of Pivotal Response Treatment and a robot-based Pivotal Response Treatment on social and communicative skills in children with autism spectrum disorder

The primary objective of the current study is assessing the effectiveness of robot-based PRT on top of care-as-usual compared to care-as-usual only. The primary hypothesis is:1) Robot-based PRT is more effective compared to care-as-usual only in:-…

Virtual Reality to Assess How Boys with Mild to Borderline Intellectual Disabilities Behave in Social Situations

The first aim is to investigate whether SIP indicators measured with VR are better predictors of aggression in real-life than SIP indicators measured with hypothetical vignettes in youth with MID-BIF. The second aim is to explore whether we can…

Bumetanide for the Autism Spectrum Clinical Effectiveness Trial

The primary objective of the study is to test the effectiveness of bumetanide across the whole spectrum of sensory processing disorders within ASD, ADHD and/or epilepsy. We also want to determine which subgroups (high/low IQ, comorbidities or not)…

Using Interactive Virtual Reality Exposure to Understand Aggressive Behavior Problems in Youth; A pilot-study

The current pilot-study aims to validate Virtual Reality (VR) environments that elicit variance in virtual aggression and social information processing (SIP) and consist of the following research questions.1. Do children experience VR environments…

Bumetanide to Ameliorate Tuberous Sclerosis Complex Hyperexcitable Behaviors

Primary aim: to confirm that treatment with bumetanide improves daily life functioning and reduces behavioral symptoms related to hyperexcitability in children and adolescents with TSC.Secondary aim: to identify neurophysiological and cognitive…

Using Interactive Virtual Reality Exposure to Understand Social Information Processing (SIP) and Aggressive Behavior Problems in Youth.

The research questions are: 1. Is SIP and behavior measured in VR more predictive of aggression in real-life than SIP and behavior as measured through hypothetical vignettes? It is expected that SIP and behavior as measured in VR is more predictive…