58 results
The primary objective of the study is to test the effectiveness of bumetanide across the whole spectrum of sensory processing disorders within ASD, ADHD and/or epilepsy. We also want to determine which subgroups (high/low IQ, comorbidities or not)…
The objective is to examine how working memory functioning in children with ADHD and/or ASD as measured with the Lion game and the Monkey is influenced by context and to assess the diagnostic utility and ecological validity of the Lion and Monkey…
1) Assess the whole genome sequence (WGS) and clinical profile of the MPX families to identify how rare and common genetic variants interact to produce shared versus distinct NDDs and clinical features in individuals, or different combinations of…
The aim of this project is to examine the association and interaction between environmental and genetic factors and development over time in adults with ASD. We examine if and how genetic and environmental factors might contribute to the course of…
1. Provide post-trial access to bumetanide treatment for NDD participants.2. To test how bumetanide cohort data compare to the existing RCT data in terms of treatment effectiveness by using randomization tests. 3. To further develop EEG biomarker…
The purpose of the study is to identify genes and genetic mechanisms that contribute to TD, chronic tics, and related clinical disorders including OCD and ADHD in individuals with these clinical phenotypes and their relatives.
In this study, we aim to describe cognition and behaviour in patients with DS and analyse correlations between behavioural difficulties and various characteristics including: seizure severity; medication use; level of cognitive functioning; and…
(a) investigate long term functional outcomes of ADHD; *(b) identify factors that predict a favourable as well as non-favourable outcome/trajectory of ADHD;(c) investigate long term effects of the use of stimulants; in kaart te brengen.
In this study we aim to further characterize E/I balance (at different translational levels), and its relation to metabolic- and immune processes, clinical profiles, behavior and cognition
We aim to study the association between (clusters of) genes or genetic pathways and phenotype in a population of people with a rare genetic variant and a (suspected) ASD. We will do this by 1) describing the individual participant, 2) comparing…
Our primary objective is to investigate the relation between atypical IMP and SINDA scores in infancy and symptoms of DCD at 4-5 years of age measured with the Movement Assessment Battery for Children - 2nd edition. The relation will also be…
The main objective of this study is to identify similarities and/or differences in social cognition between males and females with ASD at the behavioral, neuropsychological, and neurophysiological level during adolescence.
To define a link between excitatory/inhibitory (glutamate/GABA) neurotransmission and neural functioning across different brain regions (regional specificity) and to establish the relation between this link and ASD symptomatology (tapping into…
The main aim of this proposal is to characterize the neurobiological basis of sensory processing deficits in ASD. The first key objective is to exploit our Netherlands Autism Register to pre-select extreme cases of high- and low sensory sensitivity…
To evaluate the long-term neurodevelopmental outcome in two groups of children with FNAIT. First, children with unanticipated disease *index cases* that were born without maternal IVIg administration during pregnancy. Second, children with…
The main objective of this study is to identify prognostic, stratification, and/or outcome biomarkers for ASD. Prognostic marker refers to any objectively measurable test that helps to predict a child's likely developmental course; whether his…
Our primary objective is to compare children with FXS with children with non-syndromic ASD, a developmental delay (DD) and typically developing (TD) children on three domains: ASD severity, cognitive abilities and (neuro)biological characteristics.…
Primary aim: to confirm that treatment with bumetanide improves daily life functioning and reduces behavioral symptoms related to hyperexcitability in children and adolescents with TSC.Secondary aim: to identify neurophysiological and cognitive…