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A placebo-controlled discontinuation trial of off-label used risperidone in people with intellectual disability

The primary objective of this study is: To study the effect of controlled discontinuation of long-term used risperidone, for the treatment of challenging behavior, on behaviour and health. Our hypothesis is that long-term use of risperidone for…

Off-label use of Risperidone in Children and Adolescents (ORCA): a double-blind placebo-controlled discontinuation trial

Primary Objective: To investigate the behavioral effects of controlled discontinuation as well as the feasibility of discontinuing currently ongoing treatment with risperidone in children and adolescents with behavioral problems who have used…

Intervention program to improve attention and working memory for schoolaged children with behavioral- and learning problems

The aim of study I is to compare the two working memory interventions, Cogmed and the intervention developed by the Bascule, in a sample of 100 children with ADHD and working memory deficits, aged between 8 and 12 years old. Effects on working…

A randomized double-blind, placebo-controlled study of risperidone in the treatment of DSM-IV-TR conduct disorder in children and adolescents.

The primary objective of this study is to test the hypothesis that risperidone given orally in a dose of 0.25 - 3.0 mg/d depending on body weight (eq. to approximately 0.01 - 0.04 mg/kg/d) for 12 weeks is superior to placebo in reducing disruptive…

Relapse prevention in children and adolescents with DSM-IV Conduct Disorder treated with Risperidone: a Randomized Double blind, Placebo-Controlled, Discontinuation Study.

The primary objective is to test the hypothesis that, after at least 15 weeks of daily administration (4 for titration, 7 of relatively stable dose, 4 at fixed doses; Study Period II), risperidone given orally in a dose of 0.25 - 3.0 mg/d depending…

The effects of long-acting methylphenidate on academic activity and related constructs in children with ADHD: A randomised placebo controlled trial

See page 9Primary Objective:The primary objective of this study is to explore the relationship between MPH and academic activity and the mediating roles of ADHD behaviours, cognitive deficits and motivational deficits in this relationship. Therefore…

A Randomized, Double-Blind, Placebo-Controlled Trial of Adjunctive Troriluzole in Obsessive Compulsive Disorder

2.1 Primary The primary objective of the study is to evaluate the efficacy of troriluzole as adjunctive therapy compared to placebo in subjects with OCD who have had an inadequate response to their current OCD treatment based on the change in their…

Diet and Aggression: Reducing aggression among chronic psychiatric inpatients through supplementation of multivitamins, minerals and n-3 fatty acids

The main objective in this study is to test the hypothesis that suppletion with vitamins, minerals and n-3 fatty acids in long-term psychiatric inpatients will reduce the number of aggressive incidents.

A multicenter double blind randomized crossover study comparing the impact of dorsal versus ventral subthalamic nucleus deep brain stimulation on apathy in Parkinson*s disease

In this study, we will test whether STN-DBS related apathy can be reversed by switching stimulation to a more dorsal contact on the electrode.

Combining emotion recognition training with oxytocin administration: A psychobiological approach

The primary aim of this study is to examine the effectiveness of a psychobiological intervention combining oxytocin administration with ERT. We hypothesize that the combined intervention will be more effective in improving emotion recognition skills…

Reducing Aggressive behaviour among People with an Intellectual Disability through Supplementation of Vitamins, Minerals and n-3 Fatty Acids

The objective of this study is to test whether supplementation of vitamins, minerals and n-3 fatty acids may reduce aggressive behavior in people with intellectual disabilities. The research is relevant for the practice of social work. The…

Efficacy of amantadine on behavioural and emotional problems and impairment of executive functioning
due to acquired brain injury to the frontal lobes: a series of single case experimental design studies.

Objective: The objective of this study is to establish the effectiveness and safety of amantadine on emotional lability/irritability, aggression, apathy and impaired executive functioning due to frontal lobe brain injury.