13 results
Primary objective- To assess the effects of Org 25935 on heavy drinking in subjects with alcohol dependence.Secondary objectives- assess the effects of Org 25935 on the amount of drinking- To assess the effects of Org 25935 on the first relapse to…
To establish if and how the endocannabinoid system is involved in ADHD and related symptoms. This will be investigated by assessing the acute effects of a cannabinoid agonist (THC) on brain function related to ADHD and ADHD symptoms.
The proposed research project will examine the potential benefits of a *gamified* working memory training for adolescents in addiction care. The primary objective is to test whether a gamified working memory training will lead to improved working…
The main objective of this study is to determine whether THC, the primary psychoactive ingredient in cannabis, modulates activity in functional brain systems. We test this by assessing the acute effects of THC on the reward system, the working…
The main objective of this study is to determine whether and how the endocannabinoid system is involved in psychiatric disorders. We test this by assessing the acute effects of a cannabinoid agonist (THC) on brain systems that are known to be…
The main objective of the study is to find an instrument that can be used to objectively establish improvement in adults with ADHD with treatment with OROS-Mph, so that adherence to treatment can be increased and so that patients and docters can…
To assess whether treatment with DBS can reduce or resolve TDD and if DBS can induce beneficial or side effects in particular psychiatric and or cognitive symptoms.
To characterise and compare neurobiological mechanisms underlying behavioural effects of three different rTMS treatment protocols in OCD using multimodal neuroimaging, with a focus on neuroplasticity.
Primary- To investigate the safety and tolerability of JNJ-55363932 after single oral dose administration(ascending dose levels) in healthy participants- To characterize the PK of JNJ-55363932 in plasma, cerebrospinal fluid (CSF) and urine…
The aim of the study is to investigate whether inhibition of the left or right insula has differential effects with regard to clinical outcomes (i.e. smoking cessation/reduction), cognitive processes (i.e. cognitive control, craving and goal-…
The primary goal is of this pilot study is to investigate the effects of Computerised Interactive Remediation of Cognition - a Training for Schizophrenia (CIRCuiTS), on the cognitive functioning of the described group of service users. It is…
We aim to evaluate the efficacy of an add-on trans-diagnostic ACT-group in adolescents (17-37 years), which is implemented in a mental institution in Amsterdam, the Netherlands.We hypothesize that there is a beneficial effect of an eight-week add-on…
The primary objective of this study is to assess tolerance and efficacy of 12 weeks BP1.3656 (30 µg or 60 µg OD versus placebo) to reduce alcohol consumption in alcohol dependent patients.