177 results
The aim of this study is to assess the differences in the pharmacokinetic properties of clozapine and norclozapine when clozapine is used OID or BID in psychiatric patients, examining both clozapine and norclozapine concentrations and its unbound…
The objective of this study is to investigate whether patients with a good premorbid functioning have a beter treatment response after treatment with Risperdal® Consta® than those patients with poor premorbid functioning. Premorbid functioning of…
In the present study we are interested in the interaction between these two deficits in patients with schizophrenia using faces as visual objects. One of the important issues that will be addressed is that if the emotional content represented by the…
1) To compare between treatment responders, treatment non-responders, and healthy controls: sDSC and GABA in the ACC;2) To assess, in psychotic patients and healthy controls, whether AEA and 2-AG plasma levels are associated with sDSC, and…
The primary objective of this study is to determine if the binding of [11C]PK11195, as a measure of neuroinflammation, in schizophrenic patients is decreased after simvastatin treatment.
Primary objectives- To investigate CSF autoantibodies (NMDAR, AMPAR, VGKC, and GABA receptors) in patients with a psychotic disorder and healthy controls. - To compare levels of immune parameters between patients with a psychotic disorder and…
The aim of this study is to investigate how many patients with an early and/or chronic psychotic disorder reach personal recovery during follow-up and which determinants and processes influence personal, clinical, functional and societal recovery…
Objectives: Primary objective: - To investigate whether high-resolution glutamate levels in the brain of patients that experienced a psychosis differ from healthy individuals.Secondary objectives:- To compare the high resolution glutamate…
The primary objective is to investigate if there is a difference in the performance on tasks measuring visual perception and attention between visual hallucinating schizophrenic patients, schizophrenic patients who do not hallucinate and healthy…
The aim of this project is to determine the value of a dynamic network approach to predict illness course and outcome of early psychotic symptoms.
We aim to prevent or reverse developmental regression in patients with Kleefstra syndrome. We hypothesise that the regression we observed is the result of a psychotic disorder, which isnot properly recognised by clinicians and often not treated…
The goal of this study is to collect pilot data using the neuromelanin sensitive MRI sequence in patients with schizophrenia of psychoses, patients with Parkinson's disease and healthy controls. These pilot data will be used for grant…
Managing victimization risks attached to societal participation by people with severe mental illness
The main objective of the study is to gain insight in the effectiveness of the Victoria modules, in terms of acknowledgement for these experiences and risk awareness. These experiences and insights can be used to take acceptable risks in…
We propose to investigate the effect of administering a broad-acting, potent immune suppressive agent early in the course of the disease as this may prevent neuronal damage caused by low-grade inflammatory processes in the brain. It is expected that…
Objectives:This research aims to develop an appropriate lifestyle intervention for patients living in sheltered housing services of GGz Central, based on input of patients and directly involved. Does applying this lifestyle treatment result in a…
1.1 Primary ObjectiveTo test the validity and reliability of two new VR emotion recognition tasks in people with psychotic disorder. This will be done by comparing the tasks to classical tests and to compare data of people with a psychotic disorder…
Objective: The main objective of this study is to discover how asylumseekers with a psychotic disorder who are experiencing paranoid delusions behave and evaluate threat in a virtual environment. Secondary objectives: To assess the suitability and…