103 results
In the last ten years there has been a lot of research to understand persecutory delusions, but these findings had not yet been translated into treatment until Freeman and colleagues (2011). They targeted worry, but showed that rumination has to be…
-to investigate the mass balance following a single oral dose of 14C-labeled research medication-to investigate the pharmacokinetics of total radioactivity in plasma and whole blood-to investigate and quantitate metabolites of the research…
In this study, the binding of JNJ-40411813 to the brain cells and the concentration of JNJ-40411813 in the blood will be studied. Furthermore, the safety and tolerability of JNJ-40411813 will be investigated upon administration of JNJ-40411813,…
To examine the effect of L-dopa addition to optimal D2-blocking antipsychotic treatment on positive symptoms, negative symptoms, cognitive symptoms and extrapyramidal symptoms in schizophrenia.
Primary ObjectivesThe primary objective is to explore the tolerability, safety and treatment response (maintained/improved efficacy), based on total Positive and Negative Syndrome Scale (PANSS) score, of a transition to flexibly dosed paliperidone…
To determine whether changes in affect of patients with schizophrenia occur after starting clozapine.
The objective is to acquire information about the experiences of people receiving mental health treatment in the Netherlands and to contribute to international knowledge on a topic of importance to all public mental health systems.
The potential for risperidone to induce hyperprolactinemia in pediatric patients is well known.However, the effects of drug-induced serum prolactin elevations on growth and sexual maturation havenot been as well characterized in pediatric…
The following hypotheses are tested in the current study: 1) Metacognitive training is more effective than the standard treatment (TAU) for changing paranoid thinking in patients with psychotic disorders. Subhypothesis: 1a) Metacognitive training is…
The objective of this project is to assess the applicability of [11C]GMOM for in vivo imaging of the NMDA receptor.
This proposal entails a proof-of-concept study into the neuropsychological effects of memantine augmentation in a random cross-over comparison to placebo, as add-on treatment to ongoing clozapine in severely mentally ill (SMI) patients with…
- to examine the safety and tolerability of the research medication- to examine how the research medication is absorbed, broken down and excreted by the body.
The main objective is to find a pre- and post-valaciclovir treatment difference in hippocampal inflammation, as measured with positron emission tomography, in schizophrenic patients exposed to a psychotic episode. The secondary objective is to…
to assess the safety and tolerability of single ascending doses of RO5545965 in healthy subjectsto investigate the pharmacokinetics (PK) of RO5545965 (and its metabolite(s) if appropriate)to investigate the pharmacodynamic (PD) effects of…
The primary objectives of the study are to:• Evaluate efficacy of 24 weeks treatment with RO4917838 in the PANSS negative symptom factor score in patients with persistent, predominant negative symptoms of schizophrenia treated with antipsychotics.•…
The objective of this pilot study is to collect data in psychotic patients to design a subsequent larger randomised control study. An applied game using biofeedback has been developed by an independent game studio based. This game will be used to…
Transcranial magnetic stimulation (TMS) is a non-invasive, save method to stimulate the cerebral cortex and thereby alter neuronal function. In TMS a coil, which delivers brief magnetic pulses is placed adjacent to the scalp. The magnetic field…
The objective of this study is to see wether the use of eye movement treatment (EMDR) reduces the emotionality en vividness of imagery (mental images) above 'recall only'. This is a first study which may be the predecessor of a larger…
We propose to investigate the effect of administering a broad-acting, potent immune suppressive agent early in the course of the disease as this may prevent neuronal damage caused by low-grade inflammatory processes in the brain. It is expected that…
Primary objective of this study is to investigate if the Metacognitive Reflection and Insight Therapy (MERIT) improves metacognitive abilities in people with schizophrenia. Secondary objective is to examine whether improvement in metacognitive…