103 results
To examine the effect of an algorithm based polypharmacy revision strategy in schizophrenia patients treated with at least 2antipsychotics on personal and social functioning (primary outcome) and the proportion and duration of realized antipsychotic…
zie Nederlandse versie; na overleg met uw eigen METC werd vermeld dat een Engelstalige versie niet nodig was.
The aim of the study is to gain insight, based on 30 N=1 trials, into whether intensive ESM monitoring can be used to evaluate the consequences of dose reduction of antipsychotic medication by detecting meaningful within-subject changes in daily…
In this study we will investigate how quickly and to what extent ralmitaront is absorbed, transported, and eliminated from the body (this is called pharmacokinetics). Ralmitaront is radioactively labelled with carbon 14 (14C). In this way…
- Characterization of the CNS PD profile of IV administered biperiden- Characterization of the pharmacokinetic profile of IV administered biperiden- To confirm the plasma concentration-effect relationship of biperiden using population PK-PD modeling…
Primary Objective: Investigate whether EMDR Flash Forward is an effective intervention to process the mental images of worst case scenarios that occur in paranoid delusions, in order to decreases the preoccupation with the delusion.Secondary…
Objective: We aim to optimize the application of an existing drug, metformin, for a new indication, AiWG, by showing that metformin in combination with lifestyle interventions reduces AiWG compared to placebo in combination with lifestyle…
The objective of this study is to examine the effect of riluzole on the glutamate/GABA balance in the brain in patients with 22q11.2DS. The secondary objective is to examine the effects of riluzole on psychotic symptoms and cognitive functioning. In…
The primary objective is to investigate the potential effect of the AIDP on global functioning in patients with SSD, BD, AD, and PD. Secondary objectives are to investigate whether the AIDP has a beneficial effect on cognitive functioning, well-…
The objective of this study is to assess the added value of polygenic risk scoring in psychiatric genetic counseling for patients with serious mental illness (SMI) and their family members. The secondary objective of this study is to explore…
Primary objectives:Is IBA an effective treatment for patients with paranoia, that is, does IBA result in reduction of paranoia symptoms?Secondary objectives:Does insight improve after IBA treatment (i.e. insight in psychosis)?
The aim of the proposed study is to investigate the effects of antipsychotic medication on total brain volume and specific brain structures known to be affected in schizophrenia, such as hippocampus, thalamus, caudate, parietal and prefrontal cortex…
This study has been transitioned to CTIS with ID 2024-518769-80-00 check the CTIS register for the current data. Objective 1: to conduct a pragmatic single blind randomised superiority trial (RCT) testing the following hypotheses:1. social recovery…
The primary objective of this trial in CIAS is to assess the efficacy in improving cognitive impairment using MCCB in patients with schizophrenia treated for 26 weeks with Iclepertin 10mg as compared with placebo.
Our main aim is to test the effectiveness of a personalized sport intervention, which aims to promote social integration through sport activities in the community.
To test the effect of a novel VR treatment for social interaction difficulties (VR-SOAP) on quantity and quality of social contacts, leisure activities and social participation of young people with a psychotic disorder. Furthermore, to investigate…
In preparation of a larger intervention study, the aim of the current feasibility study is to test and improve a personalized sport (psychomotor therapeutic) intervention for young people in the first episode of psychosis.
objective is to assess feasibility, tolerability and efficacy of aiTBS in patients with bipolar depression (BPD) and negative symptoms of schizophrenia (NSS).
The main objective of this study is to assess the potential beneficial effects of the prebiotic Galacto-oligosaccharides (GOS) in combination with 2*-fucosyllactose (2*-FL) on the gut microbiota, by showing a relative increase in Bifidobacteria in…
The main objective of this study is to investigate the feasibility of a larger single-blind, randomized trial focused on (cost) effectiveness and safety of ECT vs. aripiprazole addition in patients with schizophrenia spectrum disorders (SSD)…