103 results
Primary objective (after 1 year)- To evaluate the effectiveness of the nurse-led GILL eHealth intervention in patients with serious mental illnessSecundary objectives (after 1 year)- Improve metabolic syndrome severity- Improve fitness, physical…
This study has been transitioned to CTIS with ID 2024-511560-93-00 check the CTIS register for the current data. The objective of this trial is to collect additional safety data.The further objective of this trial is to collect long-term efficacy…
Our primary objective is to test the effects on researcher-rated severity of PTSD symptoms of a full dose of prolonged exposure therapy (PE), eye movement desensitization and reprocessing therapy (EMDR), cognitive restructuring therapy without…
Primary objectives (after 1 year): - to improve smoking cessation- to reduce number of smoked cigarettes Secondary objectives (after 1 year): - to reduce psychiatric symptoms such as depression, psychotic symptoms and anxiety- to improve physical…
The objective of this study is to pilot this novel VR treatment for social interaction difficulties (VR-SOAP) in preparation of a subsequent randomized controlled trial (RCT). The aim of the study is threefold: 1) to investigate the feasibility and…
Primary Objective: To test whether the Feeling Safe-NL programme is more effective in improving wellbeing over time than CBTp (from baseline to 18-month follow-up).Secondary objectives: To test whether the Feeling Safe-NL programme is more effective…
The primary objective of the study is to determine whether DiSCoVR improves social cognition. We are interested in the effect of DiSCoVR on the following social cognitive domains:- Emotion Perception.- Social Perception.- Theory of Mind.The second…
To investigate if VRcbt is more (cost-)effective than standard CBT for treatment of paranoid delusions and improving daily life social functioning of patients with schizophrenia and related psychotic disorders.
Our study has two primary objectives. The first is to investigate whether EMDR-treatment will lead to a decrease in the negative impact of fear-inducing AVH. The second objective is to investigate whether the EMDR-treatment will also lead to a…
This study examines whether MCT is effective in patients with schizophrenia-spectrum disorder and comorbid GAD. It is expected that:a) MCT leads to a significant decrease in worryingb) MCT leads to significant reduction of psychotic symptomsc) The…
The primary objective of this trial is to investigate the proposed beneficial effect of simvastatin on total symptom severity (PANSS) ascompared to placebo when given in addition to antipsychotic medication, and the effects on neurocognitive…
The primary goal is to study the feasibility of schematherapy for AVH's.
The aim of this study is to assess the differences in the pharmacokinetic properties of clozapine and norclozapine when clozapine is used OID or BID in psychiatric patients, examining both clozapine and norclozapine concentrations and its unbound…
The objective of this study is to investigate whether patients with a good premorbid functioning have a beter treatment response after treatment with Risperdal® Consta® than those patients with poor premorbid functioning. Premorbid functioning of…
The primary objective of this trial is to investigate the proposed beneficial effect of raloxifene as compared to placebo when given for twelve weeks in addition to antipsychotic medication to patients with a psychotic disorder. We expect lower…
The main goal is to investigate whether COMET can be used as an intervention to reduce paranoia in patients with psychotic disorder and paranoid thoughts. An aim is also to see if the treatmenteffect is stable after eight weeks.
This study aims to examine the effectiveness, feasibility, and applicability of the adapted and translated CR from Mullen and colleagues (2017), named Mindset, for students with psychotic problems in the Netherlands.
The primary objective is to test the effects of temstem on distress, disturbance to life and social functioning. Second, we aim to investigate the effect of temstem on frequency and severity of AVH, to determine working mechanisms, to identify…
The primary objective of this study is to compare microglia activation as measured with proton Magnetic Resonance Spectroscopy (1H-MRS) between recent-onset schizophrenia patients who are randomised to CBD and those randomised to placebo. Secondary…
The current project aims to investigate the efficacy of a new form of treatment that integrates ACT in the daily-lives of ARMS individuals using a small digital device (PsyMate®). We hypothesise the ARMS and FEP individuals who receive the…