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A randomized, open label balanced two period, two-treatment, two-sequence crossover study to evaluate the effect of food on the pharmacokinetics of buspirone after a single oral administration of Lybridos in healthy female subjects

Primary objective1. To determine the effect of food on the pharmacokinetics of buspirone administered as the Lybridos formulationSecondary objective1. To evaluate the safety and tolerability of a single dose of Lybridos under fasted and fed…

A double blind, randomized, placebo controlled, cross-over study to validate the predictive power of the demarcation formula for Lybrido and Lybridos efficacy in women with female sexual interest/arousal disorder, in the domestic situation.

Primary Objective• To validate the existing demarcation formula (consisting of psychometric and biological markers) which predicts the sensitivity to Lybrido or Lybridos in women with female sexual interest/arousal disorder (FSIAD with or without…

Phase 1-3 development of a questionnaire for assessing sexual health in cancer patients:
A cross cultural project of the EORTC Quality of Life Group

The aim of this project is to develop a comprehensive EORTC questionnaire for assessing sexual health for male and female patients with cancer. Given the lack of a sexual health related measure that can be used in clinical trials and in clinical…

Gender identity, sex hormones & the developing brain

To compare sex differences in brain functioning using functional magnetic resonance imaging (fMRI) in healthy pre-pubertal boys and girls with a group of children diagnosed with GID. Subjects will have a second fMRI scan, as soon as they enter…

A randomized study of an internet-based cognitive behavioral therapy program for sexuality and intimacy problems in women treated for breast cancer.

The proposed study will evaluate the efficacy of an internet-based cognitive behavioral intervention program designed to alleviate sexuality and intimacy problemens of women who have been treated for breast cancer.

A randomized, open label balanced two period, two-treatment, two-sequence crossover study to evaluate the effect of food on the pharmacokinetics of sildenafil after a single oral administration of Lybrido in healthy female subjects

Primary objective1. To determine the effect of food on the pharmacokinetics of sildenafil administered as the Lybrido formulation2. To determine whether >90% of the testosterone content is released after maximally 90 seconds after sublingual…

Central mechanisms of ejaculatory dysfunction: a multi-modal fMRI investigation

The aim of the proposed research is to assess, using multimodal fMRI, both functional (BOLD responses) and structural (white matter) cerebral characteristics of the human IELT. In turn, this could provide specific novel (neocortical) targets in the…

Sexual complaints in female cancer survivors: Is there a need for treatment?

Observational multicenter trialThe following research questions (Q) will be addressed in patients (and partners) (Q1) whether sexual problems as reported by female cancer survivors are personally distressing and if so, ( Q2) what are possible…

Sex hormones, sex chromosomes, and sexual differentiation of the brain

Our objective is to determine the role of androgens and the Y-chromosome in sexual differentiation of the brain. Women with CAIS, who only differ from typical women in that they have a Y-chromosome, and from men in that they cannot respond to…

Single-Center, Randomized Single-Blind Placebo-Controlled Five-Arm Parallel Group Study to Assess Efficacy of a Single Dose of TBS-2 Intranasal Gel at Four Time Points Post-Dose using Vibrotactile Stimulation combined with Visual Sexual Stimulation in Female Subjects with Primary and Secondary Anorgasmia

This clinical trial is being performed to evaluate the efficacy of a single dose of TBS-2 on the occurence of orgasm. This study will explore the effect of TBS-2 on inducing an orgasm following sexual stimuli in anorgasmic female subjects at four…

Sexual problems after rape in adolescent women

The main objective of the study is to investigate whether raped adolescent women suffer from sexual problems and pelvic floor problems after rape. Secondary objective is to discover potential factors that could contribute to the development of…

The effect of cognitive behavioral therapy on female sexual dysfunction:
A research that compares internet-based with face-to-face therapy

Objective of the study is to measure Cognitive Behavioral Therapy by means of internet compared to regular face-to-face therapy and waiting list at several types of sexual dysfunctions of women.

A randomized, cross-over controlled study to compare the pharmacokinetic profiles of sublingual administered testosterone solution followed by a sildenafil citrate tablet, versus sublingual testosterone and sildenafil citrate combined in one tablet in healthy premenopausal women

Primary objective:To compare the pharmacokinetics of testosterone and sildenafil citrate following administration of a sublingual solution of testosterone with an encapsulated tablet versus a combination product.Secondary objective:To investigate…

Effect of Inflammatory Bowel Disease on sexual function in men and women: A controlled study

The present study aims to extent the sparse knowledge on sexual function in IBD by 1) examining the prevalence of sexual problems in men and women with IBD (including Crohn*s disease and ulcerative colitis), 2) comparing this with the prevalence of…

A randomized, cross-over controlled study to compare the pharmacokinetic profiles of sublingual administered testosterone solution followed by a buspirone tablet, versus sublingual testosterone and buspirone combined in one tablet in healthy premenopausal women

To compare the pharmacokinetics of sublingual testosterone cyclodextrin followed by buspirone as an encapsulated tablet with administration of testosterone and buspirone as one tablet designed to release the components in a specific time-frame.

A short CBT intervention for sexual rehabilitation among women receiving radiotherapy with gynecological cancer: A pilot study.

To investigate whether a short CBT intervention for sexual rehabilitation is feasible for patients (and their partners) and professionals. The available literature underscores the importance of sexual problems after pelvic RT and the need to develop…

Retraining automatic sexual actiontendencies in women with female sexual interest/arousal disorder

The aim of this study is to investigate whether women with FSDA and women without sexual problems can be trained with an AAT to perform more approach behaviour and less avoidance behaviour to sexual stimuli. The hypotheses which will be tested are (…

The place of pelvic floor complaints and sexual abuse in the gastroenterology practice: a cross-sectional study in colonoscopy patients

The purpose of this study is to evaluate patients consulting gastroenterologists regarding their perspectives concerning delicate matters such as sexuality. Would it be helpful if the doctor brings up the subject of SA? And how many patients would…

Women*s experiences with vaginal dilator use following radiotherapy for gynaecological cancer: a qualitative study.

By investigating reasons for (non-)compliance with vaginal dilation in a sample of gynecological cancer patients receiving RT, we hope to identify facilitating and limiting factors relevant for the development of a sexual rehabilitation program.…

Pilot study: A comparison of the gold standard for measuring genital blood flow in humans with infrared thermal imaging as sex-neutral measurement

To compare the present gold standard for measuring genital blood flow in humans (for men: a mechanical penile strain gauge (Barlow-gauge) , for women: vaginal photoplethysmography) with infrared technology.