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A double blind, randomized, placebo controlled, cross-over study to validate the predictive power of the demarcation formula for Lybrido and Lybridos efficacy in women with female sexual interest/arousal disorder, in the domestic situation.

Primary Objective• To validate the existing demarcation formula (consisting of psychometric and biological markers) which predicts the sensitivity to Lybrido or Lybridos in women with female sexual interest/arousal disorder (FSIAD with or without…

A double-blind, randomized, placebo-controlled, proof of concept study to investigate the safety and efficacy of the combined administration of 0.5 mg sublingual testosterone and 10 mg tadalafil in women with hypoactive sexual desire disorder

Primary ObjectiveTo investigate the possible efficacy of combined administration of 0.5 mg sublingual testosterone and 10 mg tadalafil in increasing sexual satisfaction during sexual activity in the domestic setting in healthy female subjects with…

Single-Center, Randomized Single-Blind Placebo-Controlled Five-Arm Parallel Group Study to Assess Efficacy of a Single Dose of TBS-2 Intranasal Gel at Four Time Points Post-Dose using Vibrotactile Stimulation combined with Visual Sexual Stimulation in Female Subjects with Primary and Secondary Anorgasmia

This clinical trial is being performed to evaluate the efficacy of a single dose of TBS-2 on the occurence of orgasm. This study will explore the effect of TBS-2 on inducing an orgasm following sexual stimuli in anorgasmic female subjects at four…

A randomised, double-blind, placebo-controlled, parallel group, single centre study investigating the brain processing of visual stimuli in pre-menopausal women with generalized acquired hypoactive sexual desire disorder after 8 weeks of flibanserin (100 mg) treatment.

Change from baseline in regional cerebral blood flow in response to various visual stimuli ascertained by Positron Emission Tomography scan after 8 weeks of flibanserin 100 mg treatment.

A double-blind, randomized, placebo-controlled, proof of concept study to investigate the differences between the combined administration of 0.5 mg sublingual testosterone and 10 mg buspirone and 10 mg buspirone administration alone in women with hypoactive sexual desire disorder

To investigate the differences between the combined administration of 0.5 mg sublingual testosterone and 10 mg buspirone and 10 mg buspirone administration alone in increasing sexual satisfaction during sexual activity in the domestic setting in…

Retraining automatic sexual actiontendencies in women with female sexual interest/arousal disorder

The aim of this study is to investigate whether women with FSDA and women without sexual problems can be trained with an AAT to perform more approach behaviour and less avoidance behaviour to sexual stimuli. The hypotheses which will be tested are (…

Two-Center, In-Patient, Randomized, Placebo and Active Comparator Evaluation of the Pharmacokinetics (PK) and Safety, Along with Initial Pharmacodynamic (PD) Efficacy of Three Dose Levels of TBS-2 Intranasal Gel Applied Twice-Daily (BID) for up to Three Days in Female Patients with Hypoactive Sexual Desire Disorder (HSDD) or Anorgasmia (ANOR).

This clinical trial is being performed to evaluate the PK profile of TBS-2 administered as single and multiple (BID) doses in patients with HSDD or ANOR. In addition, the study will evaluate the initial PD efficacy and safety of intranasal TBS-2 BID…

A methodological investigation to test acute changes in female sexual desire in healthy volunteers and pre- and postmenopausal women diagnosed with hypoactive sexual desire disorders using explicit measures in a controlled laboratory setting and behavioral measures at home, in no-drug as well as placebo-controlled within subjects cross-over drug (a single dose of testosterone gel 50mg [1% in 5g] conditions.

In order to better understand sexual desire (e.g., fluctuations in desire, level of desire to distinct sexual stimuli varying in intensity, subtypes of desire disorder) it is important to examine methods for rapid detection of desire changes.…

Effect of aversive classical conditioning on sexual response in women with dyspareunia

The purpose of the present study is to clarify the assumed role of fear in women with superficial dyspareunia. The hypothesis will be tested that aversive conditioning in women with dyspareunia and control women will lead to diminished sexual…

A COGNITIVE BEHAVIOURAL GROUP PROGRAMME - PLUS FOR WOMEN WITH DYSPAREUNIA: A RANDOMIZED WAITING LIST CONTROLLED MULTI-CENTER TRAIL OF EFFICACY

Primary objective: to evaluate whether the group programme-plus improves pain during intercourse in women with superficial dyspareunia compared to women in a waiting-list control condition.