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A randomized, open label balanced two period, two-treatment, two-sequence crossover study to evaluate the effect of food on the pharmacokinetics of buspirone after a single oral administration of Lybridos in healthy female subjects

Primary objective1. To determine the effect of food on the pharmacokinetics of buspirone administered as the Lybridos formulationSecondary objective1. To evaluate the safety and tolerability of a single dose of Lybridos under fasted and fed…

A randomized study of an internet-based cognitive behavioral therapy program for sexuality and intimacy problems in women treated for breast cancer.

The proposed study will evaluate the efficacy of an internet-based cognitive behavioral intervention program designed to alleviate sexuality and intimacy problemens of women who have been treated for breast cancer.

A randomized, open label balanced two period, two-treatment, two-sequence crossover study to evaluate the effect of food on the pharmacokinetics of sildenafil after a single oral administration of Lybrido in healthy female subjects

Primary objective1. To determine the effect of food on the pharmacokinetics of sildenafil administered as the Lybrido formulation2. To determine whether >90% of the testosterone content is released after maximally 90 seconds after sublingual…

Sexual complaints in female cancer survivors: Is there a need for treatment?

Observational multicenter trialThe following research questions (Q) will be addressed in patients (and partners) (Q1) whether sexual problems as reported by female cancer survivors are personally distressing and if so, ( Q2) what are possible…

A double-blind, randomized, placebo-controlled, proof of concept study to investigate the safety and efficacy of the combined administration of 0.5 mg sublingual testosterone and 10 mg tadalafil in women with hypoactive sexual desire disorder

Primary ObjectiveTo investigate the possible efficacy of combined administration of 0.5 mg sublingual testosterone and 10 mg tadalafil in increasing sexual satisfaction during sexual activity in the domestic setting in healthy female subjects with…

Single-Center, Randomized Single-Blind Placebo-Controlled Five-Arm Parallel Group Study to Assess Efficacy of a Single Dose of TBS-2 Intranasal Gel at Four Time Points Post-Dose using Vibrotactile Stimulation combined with Visual Sexual Stimulation in Female Subjects with Primary and Secondary Anorgasmia

This clinical trial is being performed to evaluate the efficacy of a single dose of TBS-2 on the occurence of orgasm. This study will explore the effect of TBS-2 on inducing an orgasm following sexual stimuli in anorgasmic female subjects at four…

The effect of cognitive behavioral therapy on female sexual dysfunction:
A research that compares internet-based with face-to-face therapy

Objective of the study is to measure Cognitive Behavioral Therapy by means of internet compared to regular face-to-face therapy and waiting list at several types of sexual dysfunctions of women.

A randomized, cross-over controlled study to compare the pharmacokinetic profiles of sublingual administered testosterone solution followed by a sildenafil citrate tablet, versus sublingual testosterone and sildenafil citrate combined in one tablet in healthy premenopausal women

Primary objective:To compare the pharmacokinetics of testosterone and sildenafil citrate following administration of a sublingual solution of testosterone with an encapsulated tablet versus a combination product.Secondary objective:To investigate…

A randomized, cross-over controlled study to compare the pharmacokinetic profiles of sublingual administered testosterone solution followed by a buspirone tablet, versus sublingual testosterone and buspirone combined in one tablet in healthy premenopausal women

To compare the pharmacokinetics of sublingual testosterone cyclodextrin followed by buspirone as an encapsulated tablet with administration of testosterone and buspirone as one tablet designed to release the components in a specific time-frame.

A double-blind, randomized, placebo-controlled, proof of concept study to investigate the differences between the combined administration of 0.5 mg sublingual testosterone and 10 mg buspirone and 10 mg buspirone administration alone in women with hypoactive sexual desire disorder

To investigate the differences between the combined administration of 0.5 mg sublingual testosterone and 10 mg buspirone and 10 mg buspirone administration alone in increasing sexual satisfaction during sexual activity in the domestic setting in…

A short CBT intervention for sexual rehabilitation among women receiving radiotherapy with gynecological cancer: A pilot study.

To investigate whether a short CBT intervention for sexual rehabilitation is feasible for patients (and their partners) and professionals. The available literature underscores the importance of sexual problems after pelvic RT and the need to develop…

Retraining automatic sexual actiontendencies in women with female sexual interest/arousal disorder

The aim of this study is to investigate whether women with FSDA and women without sexual problems can be trained with an AAT to perform more approach behaviour and less avoidance behaviour to sexual stimuli. The hypotheses which will be tested are (…

The place of pelvic floor complaints and sexual abuse in the gastroenterology practice: a cross-sectional study in colonoscopy patients

The purpose of this study is to evaluate patients consulting gastroenterologists regarding their perspectives concerning delicate matters such as sexuality. Would it be helpful if the doctor brings up the subject of SA? And how many patients would…

Women*s experiences with vaginal dilator use following radiotherapy for gynaecological cancer: a qualitative study.

By investigating reasons for (non-)compliance with vaginal dilation in a sample of gynecological cancer patients receiving RT, we hope to identify facilitating and limiting factors relevant for the development of a sexual rehabilitation program.…

Two-Center, In-Patient, Randomized, Placebo and Active Comparator Evaluation of the Pharmacokinetics (PK) and Safety, Along with Initial Pharmacodynamic (PD) Efficacy of Three Dose Levels of TBS-2 Intranasal Gel Applied Twice-Daily (BID) for up to Three Days in Female Patients with Hypoactive Sexual Desire Disorder (HSDD) or Anorgasmia (ANOR).

This clinical trial is being performed to evaluate the PK profile of TBS-2 administered as single and multiple (BID) doses in patients with HSDD or ANOR. In addition, the study will evaluate the initial PD efficacy and safety of intranasal TBS-2 BID…

Pilot study: A comparison of the gold standard for measuring genital blood flow in humans with infrared thermal imaging as sex-neutral measurement

To compare the present gold standard for measuring genital blood flow in humans (for men: a mechanical penile strain gauge (Barlow-gauge) , for women: vaginal photoplethysmography) with infrared technology.

Research into the efficacy and cost-effectiveness of short term, cost free and anonymous sex counselling to improve (mental) health (including development of protocol and training plan)

This project has three objectives:1. DevelopmentThe development objective is to prepare the implementation of this preventive intervention on the onehand by developing and accommodating protocols for sex counselling in the important fields of…

EMDR and exhibitionism: a randomized controlled trial on reducing deviant sexual arousal

A) To test if the EMDR addiction protocol by Hornsveld and Markus (2014), as an intervention, will lead to a reduction of deviant sexual arousal in exhibitionists, within four sessionsB) To test if the treatment effect is stableC) To test if the…

Reinnervation of the clitoris and/or vaginal surface in patients with a low spinal lesion or spina bifida: the TOMAX-procedure for Women

Reinnervation of the clitoris in patients with a low spinal lesion (Th12-L1) by nerve-transposition of the ilio-inguinal nerve towards the dorsal clotiridis nerve. By restoring the genital sensation in women with low spine lesion can increase the…

A COGNITIVE BEHAVIOURAL GROUP PROGRAMME - PLUS FOR WOMEN WITH DYSPAREUNIA: A RANDOMIZED WAITING LIST CONTROLLED MULTI-CENTER TRAIL OF EFFICACY

Primary objective: to evaluate whether the group programme-plus improves pain during intercourse in women with superficial dyspareunia compared to women in a waiting-list control condition.