49 results
Primary ObjectiveThe primary objective of the study is to evaluate the effect of lemborexant 2.5, 5, and 10 mg compared to placebo on standard deviation of lateral position (SDLP) during an on-road driving test in the morning following a single dose…
Primary Objective- To demonstrate dose proportionality between 1 mg and 5 mg of PedPRM (Neurim Pharmaceuticals Ltd.) following a single oral dose in healthy male and female volunteers (treatment A and C), under fed conditions.Secondary Objectives-…
Primary Objective: To determine the effectiveness of guided CBT compared to care-as-usual in treating insomnia in the general practice.Secondary Objective(s): Secondary objectives include investigation of cost-effectiveness. Several variables will…
Will a sleep training consisting of CBT in a chronic, psychiatric population with depressive disorder and insomnia lead to a decline of sleeping problems and a increase in sleep quality? Will the results from a normal and non chronic population will…
Objective: To investigate whether acetaminophen is effective in treating self-reported sleep problems.
Our aim with this research program is to understand (1) cognitive processes during sleep onset, (2) (advanced, functional) EEG-correlates of sleep onset, (3) their interaction and (4) how these relate to the resting state.
We aim to establish whether our judgment of *misperception* is really doing justice to the condition paradoxical insomniacs suffer from. We should keep in mind that our present definition of sleep, based on the standardized polysomnographic scoring…
The effects of kidney transplantation on circadian rhythm. Focus on sleep and cardiometabolic risks.
Primary Objective: - What influence has kidney transplantation on (recovery of) melatonin production?Secondary Objective(s): - Is recovery of melatonin rhythm after kidney transplantation related to improvement of other circadian rhythms, e.g. body…
Measuring the effects of light therapy during hemodialysis on objective en subjective sleep parameters, sleepiness during dialysis, mood and melatonin rhythm. De results of this pilot study can be used to design a larger study on light therapy in…
There are three main questions:1. How effective is internet treatment of insomnia in adolescents compared with group treatment of insomnia and control groups?2. Are the principles of cognitive behavioral therapy of insomnia in adolescents correct?3…
The objective of this study is to determine whether providing feedback enhances self-help CBT for insomnia.
To evaluate the effects of JNJ-42847922, compared to zolpidem and placebo, on driving performance as assessed by the mean difference of standard deviation of lateral position (SDLP) after forced awakening using a validated driving simulator test at…
The purpose of this study is to see if JNJ-42847922 is useful for treating patients with insomnia without any other psychiatric disease. The safety of JNJ-42847922 will also be studied.
The objective of this study is the effectiveness of a cognitive-behavioural therapy for insomnia in inpatient abstinent patients in addiction care.
The object of this study is to determine the effect of a cognitive behavioral self help intervention for insomnia. It will be tested if internet delivered self-help differs from self-help via a booklet.
As part of the development of the guided web-based self-help intervention for insomnia we want to conduct a pilot study. The aim is twofold: (1)we want to know how satisfied people are with this course. Specific questions are: what are the…
The object of this study is to determine variables associated with therapy-success of a cognitive behavioral self help intervention for insomnia.
The relationship between sleep disorders and (reactive) aggression in forensic psychiatric patients.
The primary objective of this study is to examine the relationship between sleep disorders and (reactive) aggression in forensic psychiatric patients in the Forensic Psychiatric Center Dr. S. van Mesdag in Groningen. In addition to this,…
The present study aims to systematically investigate whether the thermoregulatory profile of spontaneous fluctuations and responses to perturbations differs in association with diagnosis and with individual differences in the severity of vigilance…
This study is being performed to evaluate the cognitive and psychomotor effects of the new compound LY2624803 after bedtime dosing.