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A single dose, randomized, four-way cross-over, bioavailability and food interaction study of PedPRM (Pediatric Prolonged Release Melatonin, Neurim Pharmaceuticals Ltd) and Circadin® tablets in healthy male and female volunteers.

Primary Objective- To demonstrate dose proportionality between 1 mg and 5 mg of PedPRM (Neurim Pharmaceuticals Ltd.) following a single oral dose in healthy male and female volunteers (treatment A and C), under fed conditions.Secondary Objectives-…

(Cost-)effectiveness of a guided online CBT intervention in comparison to care-as-usual for patients with insomnia in general practice

Primary Objective: To determine the effectiveness of guided CBT compared to care-as-usual in treating insomnia in the general practice.Secondary Objective(s): Secondary objectives include investigation of cost-effectiveness. Several variables will…

A Randomized, Double-Blind, Placebo- and Active-Controlled, 4 Period Crossover Study to Evaluate the Effect of Lemborexant versus Placebo on Driving Performance in Healthy Adult and Elderly Subjects.

Primary ObjectiveThe primary objective of the study is to evaluate the effect of lemborexant 2.5, 5, and 10 mg compared to placebo on standard deviation of lateral position (SDLP) during an on-road driving test in the morning following a single dose…

The influence of sleeping time and sleep efficiency, measured with actigraphy, on daytime functioning of adults with a moderate intellectual disability

The aim is to establish a correlation between sleep time and sleep efficiency, measured by actigraphy and daytime functioning (irritability, drowsiness and physical activity) of adults with a moderate intellectial disability.

Effectivity of cognitive behavioral therapy in treating insomnia in a chronic psychiatric population with a depressive disorder.

Will a sleep training consisting of CBT in a chronic, psychiatric population with depressive disorder and insomnia lead to a decline of sleeping problems and a increase in sleep quality? Will the results from a normal and non chronic population will…

Online self-help CBT for insomnia: With or without feedback?

The objective of this study is to determine whether providing feedback enhances self-help CBT for insomnia.

Acetaminophen for SLeep Problems in Elderly Patients

Objective: To investigate whether acetaminophen is effective in treating self-reported sleep problems.

Effects of light therapy on sleep, melatonin rhythm and mood in hemodialysis

Measuring the effects of light therapy during hemodialysis on objective en subjective sleep parameters, sleepiness during dialysis, mood and melatonin rhythm. De results of this pilot study can be used to design a larger study on light therapy in…

The effects of kidney transplantation on circadian rhythm. Focus on sleep and cardiometabolic risks.

Primary Objective: - What influence has kidney transplantation on (recovery of) melatonin production?Secondary Objective(s): - Is recovery of melatonin rhythm after kidney transplantation related to improvement of other circadian rhythms, e.g. body…

Sleep problems of adolescents and efficacy of treatment. A study on effective and easily accessible treatment of sleep problems of adolescents.

There are three main questions:1. How effective is internet treatment of insomnia in adolescents compared with group treatment of insomnia and control groups?2. Are the principles of cognitive behavioral therapy of insomnia in adolescents correct?3…

A self-help method for nightmares

The objective of this study is to validate a newly designed self-help treatment for nightmares. This self-help treatment is based on Imagery Rehearsal Therapy. This treatment will be validated in comparison to an exposure treatment a diary condition…

A guided web-based intervention for insomnia: a pilot study

As part of the development of the guided web-based self-help intervention for insomnia we want to conduct a pilot study. The aim is twofold: (1)we want to know how satisfied people are with this course. Specific questions are: what are the…

Evaluation of the cognitive and psychomotor effects of LY2624803 following bedtime dosing in healthy subjects

This study is being performed to evaluate the cognitive and psychomotor effects of the new compound LY2624803 after bedtime dosing.

Sleeptraining in substance use disordered patients in clinical addiction care

The objective of this study is the effectiveness of a cognitive-behavioural therapy for insomnia in inpatient abstinent patients in addiction care.

A double-blind, randomized, controlled, 3-way crossover, pilot study to evaluate the duration of effects on simulated car driving and cognitive performance after a single dose of JNJ-42847922, zolpidem and placebo in healthy subjects

To evaluate the effects of JNJ-42847922, compared to zolpidem and placebo, on driving performance as assessed by the mean difference of standard deviation of lateral position (SDLP) after forced awakening using a validated driving simulator test at…

A randomized, placebo-controlled, 2-way crossover, double-blind study to evaluate the efficacy, safety and tolerability of JNJ-42847922 in subjects with insomnia disorder without psychiatric comorbidity.

The purpose of this study is to see if JNJ-42847922 is useful for treating patients with insomnia without any other psychiatric disease. The safety of JNJ-42847922 will also be studied.

Does early identification and treatment of sleep problems
bolster psychiatric therapeutic outcome?

The major aim of the proposed project is to investigate the clinical relevance of early identification and adequate treatment of co-occurring sleep disorders in people suffering from mental disorders. The main questions underlying the present…

Explorative study on unobtrusive sleep monitoring technologies: prolonged in-home measuring in the sleep-disordered population (PRISM study)

The aim of this study is to research if the same measures of macrostructural sleep parameters and abnormal sleep behavior can be obtained with home monitoring technologies as with a clinical PSG.

A single-center, randomized, double-blind, double-dummy, placebo- and active-controlled, 4-way cross-over study to assess next-day driving performance following single and multiple evening administrations of ACT-541468 in middle-aged and elderly subjects.

Primary objective- To evaluate the effects of ACT-541468 on objective simulated driving performance, i.e., the standard deviation of the lateral position (SDLP), after single- and multiple dose administrations (i.e., on Day 1 and Day 4) in the…

The effect of protocolled cognitive behavioural therapy for insomnia (CBT-I) on sleep, vigilance, working memory and aggressive behaviour.

In this study, the objective is to examine the effect of protocolled cognitive behavioural therapy for insomnia (CBT-I) in adolescents with complex psychiatric problems and sleeping problems (problems falling asleep, staying asleep and/or waking up…