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EMDR with traumatized adolescents with a major depressive disorder

The aim of this study is to investigate the effectiveness of EMDR with traumatized adolescents (12-18 years) with major depressive disorder.

The impact of EcologicBarrier on neurocognitive measures of emotion & executive functioning

To investigate the impact of the multispecies probiotic product Ecologic*Barrier on neurocognitive measures of emotion and executive functioning.

The effects of attachment and emotion regulation on depression and anxiety

Aim of this study is to examine the mechanisms by which attachment style and emotion regulation relate to depressive symptoms and anxiety symptoms in a clinical and non-clinical Dutch population.

Light Therapy for better Mood and Metabolic control:
a randomised double-blind placebo-controlled clinical trial in patients with Type 2 Diabetes Mellitus and Depression

(1) To investigate the efficacy of LT in patients with T2DM and comorbid depression, and (2) whether LT leads to improved insulin sensitivity, and (3) whether effects on mood and metabolic control are mediated by restoration of the circadian…

A randomized, double-blind, placebo-controlled, pilot trial of probiotics in pregnant women with symptoms of anxiety and depression.

The primary objective is to assess feasibility of a food supplement (multispecies probiotic) placebo-controlled, randomised controlled, double blind intervention in pregnant women in their late second/third trimester of pregnancy, to reduce symptoms…

Bright up! A randomized, double-blind, placebo-controlled study of light therapy for depression during pregnancy.

To investigate whether bright light therapy is an effective treatment for depression during pregnancy compared with low-intensity placebo light therapy (proof-of-principle) and to investigate the late effects of bright light therapy versus placebo…

Investigating the role of rTMS in the treatment of chronic depression

(1) To investigate the effect of rTMS in a treatment set-up of 4 weeks including sham-rTMSas a control in 2 x 50 patients who have had at least two prior antidepressant therapies and psychotherapy according to the Dutch guideline of depression.(2)…

The effects of bright light therapy for depression in adults with intellectual disability.

The purpose of the present study is to investigate the effects of light therapy (with two different light boxes) on depression in people with intellectual disability (IQ *70 ) compared to standard care (care as usual).

Feasibility of online courses on healthy eating, food-related behaviour and sustainable living

The primary objectives are (1) to investigate the feasibility of online courses targeting nutrition and food-related behaviour and (2) to investigate whether the feasibility of the online courses is related to depressive symptoms. The secondary…

Mindfulness-Based Cognitive Therapy (MBCT) and Cognitive Behavioral Therapy (CBT) for Depression in Patients after Cancer: a randomized controlled trial

Primary Objective- To assess short and long-term effects of individual Cognitive Behavioral Therapy (CBT) and individual Mindfulness-Based Cognitive Therapy (MBCT) in reducing depressive symptoms in cancer patients with clinically significant…

Reducing symptoms of depression and anxiety in adolescents with inflammatory bowel disease in order to improve quality of life and the clinical course of disease

The primary objective is to determine the efficacy of a disease specific cognitive behavioral therapy program in adolescents with IBD and increased symptoms of depression or anxiety on reducing symptoms of depression. Secondary objectives are to…

An exploratory, multicenter, placebo-controlled, randomized, double-blind study to investigate the antidepressant mechanism-of-action of JNJ-42847922 in subjects with major depressive disorder.

To investigate the effect of JNJ-42847922 given as monotherapy as compared to placebo on symptoms of depression in male and female MDD patients

Vitamin D and non-specific musculoskeletal complaints in non-Western immigrants

We aim to assess the effect of high-dose vitamin D supplementation on non-specific musculoskeletal complaints in non-Western vitamin D-deficient immigrants and to determine whether improvement of mood is associated with this effect.

An exploratory, blinded, randomized, placebo-controlled study in subjects with depressive disorder to investigate the effect of minocycline on relapse after successful intravenous ketamine/minocycline-induced (partial) symptoms response

Primary ObjectiveThe primary objective of this study is to assess whether the antidepressant response to IV ketamine can be maintained by minocycline compared to placebo.Secondary ObjectivesThe secondary objectives of this study are:* To investigate…

A Randomized, Double-Blind, Placebo-Controlled, 2-Period Crossover Study to Evaluate the Effect of Intranasal Esketamine on Cognitive Functioning in Healthy Subjects

To evaluate the effect of intranasal esketamine 84 mg on cognition, and duration of cognitive effects (if present), as assessed using a computerized test battery (Cogstate®).

The implementation and (cost)effectiveness analysis of the "BeweegKuur" Depressive Symptoms in primary care

This study investigates if the BeweegKuur Depressive Symptoms is more (cost-)effective in comparison with "watchful waiting". Complementary, success factors and barriers of the implementation of the BeweegKuur Depressive Symptoms in…

Effectiveness and Cost-effectiveness of Transmural Collaborative care with Consultation Letter (TCCCL) and Duloxetine for major depressive disorder (MDD) and (sub)chronic pain in collaboration with primary care: A randomized placebo-controlled Multi-Centre trial. TCC:PAINDIP.

The objective of this study is to establish the (cost) effectiveness of transmural collaborative care including a Consultation Letter for the GP and duloxetine (TCCCL) versus Duloxetine in patients with depression that present themselves with (sub)…

Reducing relapse and recurrence in depression with continuation Cognitive Therapy: a randomized controlled trial.

The main objective of our study is to evaluate in a randomized clinical trial the long-term clinical effectiveness of brief C-PCT in high risk recurrently depressed patients (responding to A-CT), compared with care-as-usual (monitoring). High risk…

Anti-depressant Effecte of Pulsed ElectroMagnetic Fields (PEMF) in patients with treatment resistant depression

Can this effect be utilised clinically, especially in patients with major depressive disorder?

Disrupting the rythm of depression: effectiveness and cost-effectiveness and mediating factors of preventive cognitive therapy, with or without antidepressants and compared to antidepressants alone, in the prevention of recurrent major depressive disorder.

The objective of this study is threefold:1) compare the effectiveness and cost-effectiveness of brief CT added to maintenance AD versus maintenance AD alone versus guided tapering or discontinuation of AD with brief CT.2) examine whether the…