9 results
Can this effect be utilised clinically, especially in patients with major depressive disorder?
To study the effects of ARA290 on the cognitive and neural processing of emotions in healthy volunteers 7 days post-administration.
The objective of the study is to evaluate various doses of SSR125543 in first patients (outpatients with a major depressive disorder), evaluate collected information concerning tolerability, efficacy en safety. The same infomation will be evaluated…
The main purpose of the study is to support dose selection for future Phase 3 clinical trials by evaluating the efficacy and safety of four MIJ821 doses (0.0048, 0.016, 0.048 and 0.16 mg/kg) administered every other week by intravenous infusion on…
To investigate whether mifepristone (7-day, 1200 mg/day) added to treatment as usual (TAU), is more efficacious than placebo in reducing depressive symptom severity (Inventory of Depressive Symptoms-Self Rated questionnaire; IDS-SR) in patients with…
The primary objective of this study is to evaluate the efficacy of psilocybin (25 mg or 10 mg) compared to 1 mg, administered under supportive conditions to adult participants with TRD, in improving depressive symptoms, as assessed by the change in…
In a randomized control trial (RCT) with mothers with postpartum depressive symptoms the following main hypotheses will be tested:• Oxytocin will promote more sensitive caregiving during mother-infant interactions and while interacting with a life-…
To determine the efficacy of a single day individualized dosing regimen (IDR) of GH001 compared with placebo in improving depressive symptoms as assessed by MADRS in patients with treatment-resistant depression (TRD) at the end of the 7-day double-…
In the current protocol we describe 2 work packages in which we aim to perform: A. >=2 focus-groups to gauge acceptability of the smartphone-app (WP1); B. follow-up remitted patients with recurrent MDD for 1.5 year while the background app (…