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A randomized, double-blind, placebo-controlled, Phase 2b trial with an open-label extension to determine the safety and efficacy of GH001 in patients with treatment-resistant depression.

To determine the efficacy of a single day individualized dosing regimen (IDR) of GH001 compared with placebo in improving depressive symptoms as assessed by MADRS in patients with treatment-resistant depression (TRD) at the end of the 7-day double-…

Effectivity and Working Mechanisms of Schema Therapy for patients with a Treatment Resistant Depression

Main research question:Does group-based schema therapy result in a reduction of depressive symptoms when comparing symptom change during the treatment to patients* baseline symptom level?Sub research questions:Does group-based schema therapy result…

Adaptation of the life review intervention *Looking for meaning* for general practice

The aim of this pilot study is to gain insight into the impact, feasibility and acceptability of an adapted LFM course for general practice.

Smartphone based Monitoring and cognition Modification Against Recurrence of Depression

In the current protocol we describe 2 work packages in which we aim to perform: A. >=2 focus-groups to gauge acceptability of the smartphone-app (WP1); B. follow-up remitted patients with recurrent MDD for 1.5 year while the background app (…