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A randomized controlled trial into the efficacy of neurofeedback for treatment of major depressive disorder

In this study, we have the following research objectives:1. To examine if NF, by applying the above mentioned AA-protocol, is an efficacious treatment for major depressive disorder. We will conduct a RCT in which active NF will be compared to sham-…

Deep brain stimulation of the medial forebrain bundle for patients with treatment-resistant depression

Establishing efficacy of MFB DBS for TRD by comparing active DBS with sham DBS. Secondary aims are establishing an adverse events profile, establishing effects on quality of life, cost-effectiveness, (neuro)psychological and neuroimaging measures.

Precision psychiatry: Anti-inflammatory medication in Immuno-metabolic depression

This study has been transitioned to CTIS with ID 2024-513907-15-01 check the CTIS register for the current data. Among patients under treatment for depression, we will select 140 persons with IMD. In this specific group of patients, we will test…

A Randomized, Open-label, Rater-Blinded, Active-Controlled, International, Multicenter Study to Evaluate the Efficacy, Safety, and Tolerability of Flexibly Dosed Esketamine Nasal Spray Compared With Quetiapine Extended-Release in Adult and Elderly Participants With Treatment-Resistant Major Depressive Disorder Who are Continuing a Selective Serotonin Reuptake Inhibitor/Serotonin-Norepinephrine Reuptake Inhibitor

Primary objective:The primary objective of this study is to evaluate the efficacy of flexibly dosed esketamine nasal spray compared with quetiapine extended-release(XR), both in combination with a continuing selective serotonin reuptake inhibitor (…

SAMe as an epigenetic treatment of depression in people with childhood trauma, a double blind placebo-controlled trial

Primary objective is to compare changes in depression ratings in patients with childhood trauma receiving SAMe with patients receiving a placebo over a 12 week follow-up period. A number of secondary objectives will be investigated: 1. Comparing the…

A randomised non-inferiority trial of esketamine versus electroconvulsive therapy in treatment-resistant depression

Phase 1:The primary objective of this trial is to investigate whether oral esketamine is non-inferior to ECT after eight weeks of individually optimized treatment, in participants with NTRD.Phase 2:To compare the efficacy of maintenance oral…

RESPOND: Improving mental healthcare for labour migrants in the Netherlands during the COVID-19 pandemic: implementation of a stepped care program (DWM/PM+)

Primary Objective: To evaluate the (cost-)effectiveness, feasibility, and acceptability of the culturally and contextually adapted DWM/PM+ stepped-care program among labor migrants in the Netherlands during the COVID-19 pandemic in terms of mental…

RESET-TRD; a Randomised trial on oral ESketamine compared to Electroconvulsive Therapy for patients with Treatment Resistant Depression

This study has been transitioned to CTIS with ID 2024-517485-42-00 check the CTIS register for the current data. To investigate whether oral esketamine is non-inferior to ECT in achieving treatment response on depression severity in NTRD.

REMAIN: Feasibility and Acceptability of Problem Management Plus (PM+) for Refugee Adolescents Living in the Netherlands

Primary Objective: To evaluate the feasibility and acceptability of the culturally and contextually adapted WHO*s PM+ intervention for Arabic, Tigrinya and Ukrainian speaking refugee youth living in the Netherlands.Secondary Objective:1. To evaluate…

A randomised controlled trial of oral S-ketamine as add-on medication for patients with treatment-resistant major depressive disorder

The proposed study aims to examine the antidepressant efficacy of oral S-ketamine augmentation in patients with TRD treated with regular antidepressants in a double-blind randomised controlled trial. Secondary questions involve the effects of oral S…