193 results
To investigate whether mifepristone (7-day, 1200 mg/day) added to treatment as usual (TAU), is more efficacious than placebo in reducing depressive symptom severity (Inventory of Depressive Symptoms-Self Rated questionnaire; IDS-SR) in patients with…
To determine the effect of low-dose oxycodone versus placebo in individuals that either use a selective serotonin reuptake inhibitor (SSRI) such as sertraline, paroxetine, citalopram or escitalopram on ventilation at an extrapolated end-tidal carbon…
Hypothesis: 5 day multi daily neuronavigated Theta burst sessions (developed by Stanford University and coined, SNT, i.e. Stanford NeuromdulaTion protocol) are more (cost-) effective than standard 10 Hz rTMS in patients with treatment resistant…
To characterize the safety and tolerability of single intravenous (IV) doses (Part A) and intramuscular (IM) doses (Part B) of GM-2505 in healthy volunteers.
To study the effectiveness of physiotherapy plus an eHealth psychological intervention targeted at psychosocial risk factors compared to usual physiotherapy care on disability, for patients at risk of developing persistent low back pain and neck…
The main objective is to investigate whether trauma-focused therapy (TFT), as an addition to *treatment as usual* (TAU), is more effective compared to TAU only in reducing depression symptom severity in patients with CT-related depression.
Establishing efficacy of MFB DBS for TRD by comparing active DBS with sham DBS. Secondary aims are establishing an adverse events profile, establishing effects on quality of life, cost-effectiveness, (neuro)psychological and neuroimaging measures.
What is the cost-effectiveness of a cognitive control training (CCT) as an add-on intervention in elderly depressed patients (EDP)?
Preliminary guidance on how to support these patients in clinical practice will be derived. Primary objective is the change in drug concentrations in plasma (therapeutic drug monitoring) (mg/L) of the psychotropic drug after bariatric surgery (at 1…
This study has been transitioned to CTIS with ID 2024-511997-66-00 check the CTIS register for the current data. TEMPO will directly compare i) conventional 2-step reduction with ii) gradual tapering in patients with remitted MDD who use either the…
The overall aim of this explorative proof-of-concept study is to provide first evidence that treatment with VR-Moodboost will lead to symptom improvement in patients with depression. Primary objective:We hypothesize that VR-Moodboost will lead to an…
The primary objective of this study is to evaluate the efficacy of psilocybin (25 mg or 10 mg) compared to 1 mg, administered under supportive conditions to adult participants with TRD, in improving depressive symptoms, as assessed by the change in…
In the present study our main aim is to assess whether VR psycho-education will lead to a larger decrease in feelings of self-stigma for the patient, as compared to traditional psychoeducation. Our secondary aim would be to test the effect of the VR…
To study if an online brief CBT intervention is effective for anxiety and depression compared to care as usual (CAU) in patients with PCOS
The primary aim of this study is to investigate the feasibility, acceptability and user-friendliness of implementing PM+ in Dutch prisons. This is a version of PM+ that is specifically adapted to the prisoner population and prison context. The…
This study has been transitioned to CTIS with ID 2024-513907-15-01 check the CTIS register for the current data. Among patients under treatment for depression, we will select 140 persons with IMD. In this specific group of patients, we will test…
To investigate the added effectiveness of Preventive Cognitive Therapy (PCT) with oNCRT as compared to PCT on depressive symptomatology over a one-year period in 115 partially remitted depressed patients. We hypothesize that oNCRT is able to augment…
Primary Objectives* To investigate the effects of PO and IV S-ketamine and its metabolite S-norketamine on functional CNS tests up to 6h (acute effects) and 24h (delayed effects) after administration using NeuroCart test battery in healthy subjects…
To replicate the DEPREDICT algorithm (formed from external cohorts/datasets) as a valid tool for prediction of AD treatment non-response, we aim to recruit 80 patients who are treat-ed with an SSRI or SNRI and are eligible and willing to have an MRI…
Primary objective:The primary objective of this study is to evaluate the efficacy of flexibly dosed esketamine nasal spray compared with quetiapine extended-release(XR), both in combination with a continuing selective serotonin reuptake inhibitor (…