193 results
The primary objective of this study is to assess the long-term efficacy of COMP360 with respect to use of new antidepressant treatment, hospitalisations for depression, suicidality, and depressive severity rated using the Montgomery and Asberg…
Primary objective is to compare changes in depression ratings in patients with childhood trauma receiving SAMe with patients receiving a placebo over a 12 week follow-up period. A number of secondary objectives will be investigated: 1. Comparing the…
Primary objective: Determine whether a RYGB operation causes a clinically significant decrease in AUC (area under serum concentration-time curve) of citalopram three months after surgery in comparison with the situation before the operation.…
Objective/research question: What are costs and effects of group-oriented Psychiatric Rehabilitation ("Patient and Partner Education Program for All chronic diseases": PPEP4AII) in patients with Persistent Depressive Disorder and their…
1. Investigate whether characteristics of laboratory stress response predict depressive symptom severity measured by the Inventory of Depressive Symptomatology - Self-Report (IDS-SR) after 6 months among adults receiving treatment for depressive…
The primary objectives are to study the feasibility and acceptability of an 8-week daily oral supplementation with tributyrin (4 g/day) - the triglyceride form of butyric acid - on top of treatment as usual (TAU) in adults (18 up to 65 years) with…
Our aim is to develop JITAIs focused on behavioral activation (BA) for depression in close collaboration with patients and therapists, and to examine their usability, feasibility, and preliminary effectiveness.
Our primary objective in this study is to predict treatment outcome for SSRI, CBT, rTMS, esketamine, and ECT in patients with MDD with the use of biomarkers and machine learning using data obtained before a new or follow-up treatment. Our secondary…
Our primary objective is to investigate whether EMDR and Imagery Rescripting are effective for individual patients who experience intrusions: patients with PTSD, patients with depression, and patients with PTSD and a comorbid depression. To this end…
The aim of the current study is to examine the efficacy of positive CBT for the treatment of major depressive disorder in older adults. Drawing on previous findings, we hypothesize that older adults suffering from major depressive disorder profit…
To characterize the safety and tolerability of ascending single oral doses (part A) and ascending repeated oral doses (part B) of GM-1020 and the effect of food on single dose GM-1020 (part C) in healthy volunteers.
Primary Objective: To determine whether NFE + standard care is superior to standard care alone in the treatment of depression. Secondary Objective(s): To assess correlations between NFE success and brain activation / clinical changes; to assess…
This study aims to investigate the effectiveness of EMDR (n=32) in comparison to a waiting list in (n=32) adolescents (12-18 years) with a primary diagnosis of MDD (DSM-5; American Psychiatric Association, 2013). It is hypothesized that the…
Part A:- Evaluate the safety of increasing doses of a single dose continuous DMT infusion over 90 minutes in healthy smokers - Characterize the pharmacokinetics of a single dose DMT administered continuously over 90 minutes in healthy smokers -…
Phase 1:The primary objective of this trial is to investigate whether oral esketamine is non-inferior to ECT after eight weeks of individually optimized treatment, in participants with NTRD.Phase 2:To compare the efficacy of maintenance oral…
The aim of this pilot study is to evaluate the feasibility of an online platform that targets depressive symptoms in an elderly population (55+) by means of an online treatment platform (Moodbuster) for depression in a pretest-posttest design.
The primary aim of the Routine Outcome Monitoring for Geriatric Psychiatry & Science 2.0 project (ROM-GPS 2.0) is 1) to evaluate treatment outcome for affective disorders in specialised geriatric mental health care and 2) to examine the…
The aim of this project is to assess the acute effects of the N-methyl-D-aspartate receptor antagonist S(+)-Ketamine compared to placebo on body and self-perception, using cognitive experimental tasks and EEG in healthy volunteers.
In the present study we aim to investigate the effectiveness of short-term schema group therapy (protocol of de Jager and Burger) on (1) persistent anxiety and depressive symptoms, and (2) dysfunctional schemas, experiential avoidance and the mode…
This study has the following study aims: 1) Investigate whether treatment context and the addition of chronotherapeutic and social rhythm interventions improve the efficacy of BLT, 2) examine the role of circadian phase resetting and changes in…