193 results
The primary goal is to investigate the effectiveness of Imagery Rescripting as an add-on intervention to care as usual (CAU) for treating clinical symptoms of depression of 15 adolescents who have been exposed to childhood trauma. The secondary…
In a randomized control trial (RCT) with mothers with postpartum depressive symptoms the following main hypotheses will be tested:• Oxytocin will promote more sensitive caregiving during mother-infant interactions and while interacting with a life-…
Primary objectives: • To determine the safety and tolerability of a single administration and single-day IDR of intravenous GH002.• To determine the pharmacokinetics (PK) of 5-MeO-DMT in healthy volunteers following a single administration and…
To determine the efficacy of a single day individualized dosing regimen (IDR) of GH001 compared with placebo in improving depressive symptoms as assessed by MADRS in patients with treatment-resistant depression (TRD) at the end of the 7-day double-…
Primary Objective: Our primary objective is to quantify whether 8 weeks of treatment with rTMS and CBT in addition to continued pharmacotherapy will outperform the most optimal treatment as usual step (switching or augmenting antidepressants in…
Primary Objective: To evaluate the (cost-)effectiveness, feasibility, and acceptability of the culturally and contextually adapted DWM/PM+ stepped-care program among labor migrants in the Netherlands during the COVID-19 pandemic in terms of mental…
In this study, we will investigate how quickly and to what extent the study compound MIJ821 is absorbed, transported, and eliminated from the body. For this study, MIJ821 is radioactively labelled with carbon-14 (14C). In this way, MIJ821 can be…
The aim of this study is to investigate how quickly and to what extent aticaprant is absorbed, transported, and eliminated from the body (this is called pharmacokinetics). For this study, aticaprant is radioactively labelled with carbon-14 (14C). In…
The objective of this study is to detect whether stimulation during task induced activation of brainnetworks leads to a higher efficacy of rTMS and other neurobiological changes.
To explore whether influence on parasympathetic activity can be used as a functional outcome measure reflecting adequate targeting of the DLPFC-sgACC network and, secondary: 1) to explore the dose-response to the intensity of the TMS output and 2)…
The aim of the present study is to conduct a randomised controlled trial (RCT) to assess the effectiveness of a guided and unguided web based transdiagnostic intervention in treating university and PhD students with depression and/or anxiety.
In this study we will compare the (cost-) effectiveness on depression of 25- versus 50-sessions of psychotherapy (SPSP or ST) within one year in patients with depression and comorbid personality disorders. In addition we will examine the personality…
Main research question:Does group-based schema therapy result in a reduction of depressive symptoms when comparing symptom change during the treatment to patients* baseline symptom level?Sub research questions:Does group-based schema therapy result…
The primary aim of this study is to compare adherence rates between (1) people who receive a short course aimed at improving mood with automated support by a virtual coach, (2) people who receive the same course with personalized supportive messages…
We propose to study the role of rumination (moderation and mediation) in the effect of MBCT on depressive symptoms and risk factors for relapse in crMDD patients, by means of repeated questionnaire measures and an innovative on-line behavioral task…
The primary objective of this study is to compare the effectiveness and cost-effectiveness of behavioural activation (BA) and treatment as usual (TAU) for late-life depression in primary care in the Netherlands. The main hypothesis is that compared…
To examine in depressed patients who reach a stable depression remission during optimal AD treatment: 1) whether discontinuation is possible; 2) when discontinuation is possible; and 3) in whom discontinuation is possible.
The primary objective of the study is to determine whether TAK-653, in comparison to placebo, increases CNS excitability, assessed with TMS-evoked MEP in healthy subjects.Next to that, the study has the following goals: - To determine whether TAK-…
The primary aim of this study is to evaluate the effectiveness of face-to-face and online CBT (vs. waitlist) in reducing PCBD, depression and posttraumatic stress complaints in people bereaved by a traffic accident. The second aim is to study to…
The aim of this study is to describe the kinetics of venlafaxine and its metabolite o-desmethylvenlafaxine after gastric bypass surgery and to compare the kinetics of venlafaxine and O-desmethylvenlafaxine before and after a Roux-en-Y gastric bypass…