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The relation between free serotonin in plasma, serotonin in trombocytes and the genotype of the serotonin transporter in carcinoid patients, patients on selective serotonin reuptake inhibitors and healthy controls.

To determine the influence of the serotonin transporter activity on the plasma free serotonin and dopamine amount and the stored amount (in trombocytes) in three different populations (healthy controls, carcinoid patients and patients on medication…

Diagnostic Imaging of Affective Disorders using Emotion-processing in non-depressed patients
(DIADE-II).
A neuroimaging study to determine biomarkers to discriminate unipolar and bipolar depression

We aim to (1) improve differential diagnosis of recurrent MDD and BD by investigating biomarkers at a neuropsychological and neurobiological level ; (2) investigate whether affective neuropsychological testing can be used as a diagnosios tool for…

A double-blind, randomized, placebo-controlled, cross-over, single center, pharmacodynamic trial to collect data for quantitative modeling of HPA axis modulation with desmopressin and CRH in healthy volunteers

Primary objectives:1) Describe the PD effects on plasma ACTH and serum cortisol upon 100 µg hCRH injection with or without a preceding injection of 10 µg dDAVP 2 hours earlier and study the PK-PD relationship (*Block B*). In particular, the outcome…

International Study for the Prediction of Optimized Treatment - in Depression

The overall objectives of the iSPOT-D trial are to use standardised genetic-brain-cognitionprotocols to:1. Identify markers of MDD as a diagnostic group and its subtypes2. Identify markers which change with acute (8 weeks) drug treatment in MDD3.…

Development and effectiveness of a webbased psycho-educational self-management intervention for breast cancer patients.

The purpose of this study is to develop a webbased intervention for breast cancer patients to reduce the impact of psychological problems that arise after the completion of medical treatment at an early stage. The question is whether this…

A randomized, parallel, double-blind, placebo controlled trial to investigate HPA-axis activation before and after electro-convulsive therapy in patients with a major depressive episode using an orally administered 5-HTP challenge test

Primary:1. to investigate the serotonergic HPA-axis activation (cortisol, ACTH, prolactin) in patients with a major depressive episode, using a newly developed oral 5-HTP-challenge administered before the first ECT treatment.2. to investigate the…

Serotonin-transporter polymorphism, early life events and emotional information processing

The aim of this study is to further investigate the relationship between 5-HTTLPR genotype and emotional processing. Recent literature suggests that s allele carriers of the 5HTT have a greater risk of developing depression in response to stressful…

Disrupting the rythm of depression: effectiveness and cost-effectiveness and mediating factors of preventive cognitive therapy, with or without antidepressants and compared to antidepressants alone, in the prevention of recurrent major depressive disorder.

The objective of this study is threefold:1) compare the effectiveness and cost-effectiveness of brief CT added to maintenance AD versus maintenance AD alone versus guided tapering or discontinuation of AD with brief CT.2) examine whether the…

Effects and costs of a combined screening and treatment program
for elderly (aged 75 years and over) with depressive symptoms
in general practice

To study the effects and costs of a screening and treatment program for elderly with depressive symptoms in general practice.

PCI vs thrombolysis in acute myocardial infarction: a prospective study on the effects of cardiac and psychological risk factors on prognosis and quality of life SUBSTUDY: Endothelial dysfunction in ACS patients with and without depression

the proposed study will examine the differences in flow-mediated vasodilatation of the brachial artery in depressed and non-depressed post-MI patients.

Detection and treatment of major depression in patients with somatic illnesses admitted to the general hospital

The aim of the study is to:1. assess the prevalence of depression in patients with somatic illnesses admitted to the general hospital and to examine which self-report questionnaire is most suitable to screen for depression in this setting;2. to…

A double-blind, randomized, placebo controlled, single oral dose, two way cross-over trial to investigate the effects of an orally administered 5-HTP challenge test on hypothalamic fMRS activation in healthy male volunteers.

Primary Objectives:- To investigate the effects of a single dose (plasma concentration) 5-HTP challenge test (5-HTP200mg/CBD100+50mg/granisetron2mg) on hypothalamic fMRS activation patterns in healthy male volunteers.Secondary Objectives:- To assess…

Attachment relationships and (introjective and anaclitical) vulnerability factors to depression: Idiographic assessment with the Self-Confrontation Method

The objective is this study is fourfold: (1) The primary objective is the (construct-) validation of the SCM-typology. (2) A second objective is to explore the idiographic narrative assessment of depression.(3) A third objective is to explore the…

A double blind, randomized, placebo controlled four way cross-over trial to investigate the effects of metoclopramide on central vasopressin release and HPA-axis activation

Primary:1. To establish the effect of MCP on the release of plasma AVP and subsequent ACTH and cortisol secretion in the absence of a 5HTP-challenge.2. To establish the effect of MCP on the release of plasma AVP and subsequent ACTH and cortisol…

STRENGTHS: Fostering responsive mental health systems in the Syrian refugee crisis

Primary Objective:To evaluate feasibility, acceptability, effectiveness and cost-effectiveness of the culturally adapted PM+ intervention forSyrian refugees in The Netherlands.Secondary Objective(s):1. To translate and (culturally) adapt PM+ for use…

D*Phase psychotherapy study - Research on counselling for depression
What works best for whom* and when?

1. To prove that Short-Term Psychodynamic Psychotherapy (STPP) is in fact non-inferior to Cognitive Behavioural Therapy (CBT) in the treatment of Major Depression so it can be considered a treatment of first choice in the Dutch Guidelines for…

Mood Disorders in Elderly and ECT (Electroconvulsive therapy): Electroconvulsive therapy can induce brain derived neurotrophic factor in serum and increase cortisol levels to enhance neurorestorement of hippocampal volume and function.

To predict and evaluate the effectively and safety of ECT in depressed elderly.1. the relation between clinical parameters and the safety and effectively of ECT in elderly with a severe depressive disorder2. the relation between structural brain…

MOODSTRATIFICATION
Immune Signatures for Therapy Stratification in Major Mood Disorders

MOODSTRATIFICATION is a large, multi-center international study supported by the EU. Workpackage 3 aims to establish a proof-of-concept for a succesful therapy-stratification model for use in patients with a moderate to severe depressive episode.…

Understanding and overcoming patient-related barriers in the uptake of psychological care in cancer patients with depressive symptoms - To examine which symptoms of depression are most central in causing symptom spread and patients* own care needs and preferences for distinct symptoms

One possible reason why so many cancer patients with depressive symptoms indicate no care needs, could be that the offered care does not fit patients* symptoms, given the wide range of depressive symptoms (e.g. sad mood, fatigue). The objective of…

MOODSTRATIFICATION IMMUNOSTRATA Groningen
Premature immune ageing and spinning therapy in mood disorders

Primary objective:To assess whether the state of premature immune ageing (senescent CD8+ T cells) modify treatment response to physical endurance intervention therapy in depressed patients. We will compare the mood-beneficial effects of physical…