17 results
The aim of this study is to investigate the effect of guided tapering in early pregnancy as compared to continuation of SSRIs during pregnancy. We will study effects on both mother and child with a pragmatic approach.
The main objective of the study is to investigate whether a 9 week MFT for adolescents with ASD and clinically elevated internalizing symptoms, reduces adolescent's internalizing symptoms. Secondary objective is to investigate the process of…
The purpose of the present study is to investigate the effects of light therapy (with two different light boxes) on depression in people with intellectual disability (IQ *70 ) compared to standard care (care as usual).
Objective: We would like to differentiate *normative mood swings*. in adolescence from early signs of depression. A comparison between low-risk adolescents and an at risk and a clinically referred sample is needed to detect an unrecognized subsample…
Compare the clinical- and cost-effectiveness of blended cognitive behavioral treatment (bCBT) to treatment as usual (TAU) for adults with MDD in specialised ambulatory mental healthcare.
Objective: Primary objective is to demonstrate non-inferiority of the e-prescription to the use of antidepressants on the short term. Secondary objectives are to assess its effect on long term outcomes, antidepressant use, and to assess its…
To examine the protective effects of a single session of high frequency rTMS over the left dorsolateral prefrontal cortex on negative mood and motivated attention.
Main objectives: This exploratory intervention study is set out to examine effects of tailor-made lifestyle advice, based on observed individual temporal patterns of lifestyle factors and experienced pleasure, as a non-pharmacological means to…
Firstly this study tries to answer the question whether applying well-being therapy to outpatients with a mild affective disorder in Dutch mental health care, reveals a trend in which well-being is increased and psychiatric complaints are reduced.…
The primary objectives :Are children of mothers with sub-optimal thyroid function and/or sub-clinical hypothyroidism and/or hypothyroxinemia during early pregnancy at risk for developmental delay at the age of two and does this possible delay…
Primary Objectives(1) investigate the safety and tolerability of JNJ-54175446 after multiple consecutive dose administrations;(2) investigate the plasma pharmacokinetics of JNJ-54175446 following multiple dose administration in healthy male subjects…
The main objectives of the trial are* To develop innovative evidence*based, feasible, effective and sustainable nutritional strategies for the prevention of depression in EU citizens.* To establish the feasibility and effectiveness of nutritional…
This explorative feasibility study will focus on developing a treatment protocol for light therapy in older adults with dementia and a depressive disorder. However, it is important to first consider whether the treatment is feasible at this target…
The current pilot study aims to examine the feasibility of the module when added to an existing problem-solving intervention, *Alles onder Controle*, for reducing symptoms of anxiety and depression. Additionally, we aim to get first insight in…
Primary Objective:To investigate the safety and tolerability of JNJ-42847922 in subjects with MDD. Study medication will be administered for 10 days in women of childbearing potential (WOCBP) or for 4 weeks in all other subjects.Secondary Objectives…
The primary aim of this study is to understand the neurocognitive mechanisms by which preventive cognitive therapy obtains its preventive effects in remitted depressed patients. Using functional MRI in combination with pupillometry and…
The primary goal of this research project is to improve mental healthcare for patient suffering depression in the Netherlands as well as in other countries. The outcomes can help increase the quality of life for a large group of people and it can…