25 results
MOODSTRATIFICATION is a large, multi-center international study supported by the EU. Workpackage 3 aims to establish a proof-of-concept for a succesful therapy-stratification model for use in patients with a moderate to severe depressive episode.…
The primary aim of the current research is to gain insight into the background, and the precipitating factors of the suicides among adolescents aged, 10 to 20 years old, in 2017 in the Netherlands, by focusing on five domains and the last period…
Primary Objective: The primary objective is to establish the differential and sequential effectiveness of cognitive restructuring (CR) and behavioral activation (BA) (and the optimal sequence of these elements) on depressive symptoms (PHQ-2 at post…
Primary research question:- Does treatment with drugs modulating vasoconstriction, i.e. COX-inhibitors (acetaminophen) or calcium-antagonists (nimodipine), improve electrographic postictal phenomena?Secondary research questions:- Does treatment with…
In addition to the above mentioned background of this research, it is important to investigate the effectiveness of psycho-education in depressed patients within specialized mental health care. In this study, the focus is on self-efficacy, because…
Primary objectives* To determine if 3-month PMTERGO decreases depressive symptoms in subjects with MDD* To determine if 3-month PMTERGO alters in vivo striatal DRD2/3 BP compared to pre-intervention levels in subjects with MDDSecondary objectives:*…
What is the cost-effectiveness of a cognitive control training (CCT) as an add-on intervention in elderly depressed patients (EDP)?
Preliminary guidance on how to support these patients in clinical practice will be derived. Primary objective is the change in drug concentrations in plasma (therapeutic drug monitoring) (mg/L) of the psychotropic drug after bariatric surgery (at 1…
- To identify the relationship between fatigue and effort-based decision making in cancer survivors- To test whether effort-based decision making differs between cancer survivors and controls
The main descriptive and analytic objectives are: Descriptive: To gather epidemiological evidence (prevalence, incidence) about the course of the mental, musculoskeletal, neurocognitive and cardiovascular health (dependent variables) of professional…
Primary Objective: Our primary objective is to quantify whether 8 weeks of treatment with rTMS and CBT in addition to continued pharmacotherapy will outperform the most optimal treatment as usual step (switching or augmenting antidepressants in…
Objectives: - To identify and compare motivational behaviour in patients during different phases of cancer treatment. - To test its associations with self-reported fatigue/depression. - To determine to what extent treatment regimen, inflammation,…
The primary aim of this study is to compare adherence rates between (1) people who receive a short course aimed at improving mood with automated support by a virtual coach, (2) people who receive the same course with personalized supportive messages…
We propose to study the role of rumination (moderation and mediation) in the effect of MBCT on depressive symptoms and risk factors for relapse in crMDD patients, by means of repeated questionnaire measures and an innovative on-line behavioral task…
To examine in depressed patients who reach a stable depression remission during optimal AD treatment: 1) whether discontinuation is possible; 2) when discontinuation is possible; and 3) in whom discontinuation is possible.
The primary aim of this study is to evaluate the effectiveness of face-to-face and online CBT (vs. waitlist) in reducing PCBD, depression and posttraumatic stress complaints in people bereaved by a traffic accident. The second aim is to study to…
The aim of this study is to describe the kinetics of venlafaxine and its metabolite o-desmethylvenlafaxine after gastric bypass surgery and to compare the kinetics of venlafaxine and O-desmethylvenlafaxine before and after a Roux-en-Y gastric bypass…
The number of psychiatric patients who received euthanasia has grown from 0 in 2002 to 83 in 2016. Also the estimated number of requests has risen, from 320 in 1995 to 1100 in 2016. Although the numbers are relatively low and most of the requests…
Regarding the goal of the Society for Mental Space Psychology: to help shift the paradigm in psychology towards a more mental space oriented science, the publication of research that supports this idea is fundamental. Besides that, is the…
Primary Objective: - To examine the acceptability and feasibility of an add-on internet-based ERT training and the trial design in adolescent patients (aged 13-18) with depressive or anxiety disorders, their parents, and their therapists as…