25 results
In this study, we want to combine rTMS and CCT to assess whether the combination of these two treatment would have synergistic effects and strengthen each other. We specifically want to assess the effect on mood and cognitive control, in a group of…
This study has been transitioned to CTIS with ID 2024-518101-18-02 check the CTIS register for the current data. The main objective of this project is to associate the gut microbial community with treatment efficacy (i.e., relieve in symptoms and…
The project aims to improve mental health and wellbeing in the workplace by developing, implementing and evaluating an intervention targeting both clinical (depressive, anxiety disorders) and non-clinical (stress, burnout, depressive symptoms)…
Primary objectives:1. To investigate the safety and tolerability of JNJ-69095897 versus placebo after administration in healthy participants.2. To characterize the PK of JNJ-69095897 in blood, plasma, cerebrospinal fluid (CSF) and urine after…
The objectives of the current study, are to assess in a sample of remitted recurrently depressed patients over a 20-year follow up period: the long-term effects of PCT; the long-term predictive value of cognitive functioning on relapse and daily…
The primary aim of the proposed study is to test the effectiveness of CBT + ERT in reducing depressive and anxiety symptoms against CBT alone in adolescent patients (aged 13-19) with depressive or anxiety disorders in a randomized controlled trial (…
In this study we will investigate how safe the new compound seltorexant is and how well it is tolerated when it is used by healthy participants.We also investigate how quickly and to what extent seltorexant is absorbed, transported, and eliminated…
Primary Objective: The overarching goal of the multicentre trial is to characterize the overlap between mental and non-mental comorbid conditions of IBS. In IBS and patient control groups we will characterize depression, anxiety, fibromyalgia and…
The main purpose of the study is to support dose selection for future Phase 3 clinical trials by evaluating the efficacy and safety of four MIJ821 doses (0.0048, 0.016, 0.048 and 0.16 mg/kg) administered every other week by intravenous infusion on…
The primary objective is to research whether the oral contraceptive pill in adolescents has a negative effect on emotion regulation in the form of fear acquisition and extinction. The secondary objective is to research whether a disruptive effect of…
* to evaluate the safety and tolerability of Lu AF90103 following single ascending intravenous (i.v.) doses* to investigate the pharmacokinetics (PK) of Lu AF90103 (prodrug) and Lu AF88361 (drug) in plasma and cerebrospinal fluid (CSF) following…
To investigate whether mifepristone (7-day, 1200 mg/day) added to treatment as usual (TAU), is more efficacious than placebo in reducing depressive symptom severity (Inventory of Depressive Symptoms-Self Rated questionnaire; IDS-SR) in patients with…
The main objective is to investigate whether trauma-focused therapy (TFT), as an addition to *treatment as usual* (TAU), is more effective compared to TAU only in reducing depression symptom severity in patients with CT-related depression.
This study has been transitioned to CTIS with ID 2024-518047-37-01 check the CTIS register for the current data. The aim of our study is two folded: first, we aim to improve cognition after ECT, improving its acceptability and tolerability and hence…
The overall aim of this explorative proof-of-concept study is to provide first evidence that treatment with VR-Moodboost will lead to symptom improvement in patients with depression. Primary objective:We hypothesize that VR-Moodboost will lead to an…
Primary objective:To assess whether the state of premature immune aging (senescent CD8+ T cells) predicts treatment response to physical endurance intervention therapy in depressed patients. We will compare the mood-beneficial effects of physical…
Primary objective:- to determine the association of the intra-individual determinants and the physical environment in regulating lifestyle behaviour and in turn the occurrence of pre-T2D and T2D in the general population. Secondary Objective(s): -…
Primary:o To compare effort- and/or reward-related neural activity between cancer survivors and healthy controlso To assess whether cancer-related fatigue is related to effort- and/or reward-related neural activitySecondary objectives:o To assess…
The main objective of this study is to determine the efficacy of STAIRS. The secondary objectives are: (1) to investigate the association between improved personal recovery and depression relapse and (2) to gather qualitative insights into the…
Primary Objective: To evaluate the (cost-)effectiveness, feasibility, and acceptability of the culturally and contextually adapted DWM/PM+ stepped-care program among labor migrants in the Netherlands during the COVID-19 pandemic in terms of mental…