58 results
Primary Objective: to study the differences in CD4+ T cell subsets (Th1/Th2/Th17/Tregulatory/Tsenescent) between GCA patients and healthy controls at diagnosis and during follow up and in remission. Secondary Objective(s): - To characterize the cell…
To compare two surgical techniques in the treatment of patients with a anterior CECS.Surgical method 1: use of conventional *Due* fasciotome Surgical method 2: use of the new *Fasciomax©* in stead of the *Due*-fasciotome.
The purpose of this study is to investigate the effectiveness and safety of riociguat (BAY 63-2521) in patients with diffuse cutaneous systemic sclerosis.
This investigation aims to investigate connective tissue fibroblast activation in detail in the inflamed fibrotic connective tissue. By analyzing these cells in detail we hope to understand better how they are activated, so we can develop better and…
EFFICACY OBJECTIVESThe primary efficacy objective for this study is as follows:* To evaluate the efficacy of TCZ compared with placebo on skin sclerosis, as measured by mRSS at Week 48The secondary efficacy objectives for this study are as follows…
zie nederlandse samenvatting
-To assess the central chemosensitivity by an carbon dioxide rebreathing test-To assess mouth occlusion pressures during the carbon dioxide rebreathing test-To study the relation between these results and the results obtained with the MRI and…
Reduce postoperative chronic pain after open inguinal hernia repair.
Because the pathophysiology of SSc is unknown, there is currently no treatment available to cure the disease itself, so only individual organ system complications are treated (7,8). Therefore, treatment is patient-specific and aimed at ameliorating…
The primary objectives are:- To demonstrate the relationship of blood flow in the hands and the extent of digital ulcera in patients with systemic scleroderma;- Evaluate the effect of bosentan on the blood flow in the hands from baseline to 12 weeks…
To identify the patient profile for Actifuse and for other grafting products used to achieve bone fusion.
To compare treatment of secondary Dupuytren*s contracture by standard limited (dermo)fasciectomy and by the modified percutaneous release combined with fat grafting. We focus specifically on return to function and if applicable to return to work (…
PRIMAIRYThe primary objective of this trial is to evaluate the efficacy of atacicept compared to placeboin preventing new flares in subjects with SLE.SECONDARYSecondary objectives of the trial are:• To evaluate the safety and tolerability profile of…
To evaluate the effectiveness of CCH as treatment for Dupuytren*s contracture in the thumb and first web space by assessing pre- and post treatment extension deficit and adduction contracture.
Primairy objective:- Evaluate the effect of bosentan on the blood flow in the hands from baseline to 12 weeks, measured by laser Doppler imaging, in SSc subjects with an early or active SSc pattern, measured with nailfold capillaroscopy (NFM), with…
The aim of this study is to evaluate the safety and the outcomes of laparoscopic correction of a recurrent inguinal hernia after previous repair.
The aim of this project is to assess objective and subjective functional long-term outcome of patients with intra-articulair distal radius fractures treated with open reduction and internal fixation (ORIF). This will be done by standardized…
The proposed project focuses on: a) implementation of an improved, standardized method for performing quantitative nailfold capillaroscopy to visualize morphological patterns and evaluate its diagnostic use in patients with (possible) CTD and…
Construction of a biobank with peripheral blood and skin biopsies from patients with SSc, to evaluate (new) antigens and/or (new) antibodies and/or RNA expression profiles and to correlate these findings with clinical parameters (i.e. disease…