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Comparison between two surgical methods in the treatment of anterior chronic compartment syndrome: a patient blinded, randomized study.

To compare two surgical techniques in the treatment of patients with a anterior CECS.Surgical method 1: use of conventional *Due* fasciotome Surgical method 2: use of the new *Fasciomax©* in stead of the *Due*-fasciotome.

A Randomized, Double-Blind, Placebo-Controlled Phase II Study to Investigate the Efficacy and Safety of Riociguat in Patients With Diffuse Cutaneous Systemic Sclerosis (dcSSc)

The purpose of this study is to investigate the effectiveness and safety of riociguat (BAY 63-2521) in patients with diffuse cutaneous systemic sclerosis.

A PHASE III, MULTICENTER, RANDOMIZED, DOUBLE BLIND, PLACEBO-CONTROLLED, PARALLEL-GROUP STUDY TO ASSESS THE EFFICACY AND SAFETY OF TOCILIZUMAB VERSUS PLACEBO IN PATIENTS WITH SYSTEMIC SCLEROSIS

EFFICACY OBJECTIVESThe primary efficacy objective for this study is as follows:* To evaluate the efficacy of TCZ compared with placebo on skin sclerosis, as measured by mRSS at Week 48The secondary efficacy objectives for this study are as follows…

Trans rectus sheath preperitoneal mesh repair (TREPP) versus transinguinal preperitoneal procedure (TIPP) for inguinal hernia repair: a multi-center randomized controlled trial.

Reduce postoperative chronic pain after open inguinal hernia repair.

Effects of bosentan in a homogeneous population of SSc subjects with a predefined restriction of blood flow in the hands

The primary objectives are:- To demonstrate the relationship of blood flow in the hands and the extent of digital ulcera in patients with systemic scleroderma;- Evaluate the effect of bosentan on the blood flow in the hands from baseline to 12 weeks…

A prospective patient registry for bonegraft substitutes in spinal fusion

To identify the patient profile for Actifuse and for other grafting products used to achieve bone fusion.

A pilot randomized controlled trial comparing the effect of a percutaneous and lipofilling technique in patients with a secondary Dupuytren*s contracture with standard fasciectomy surgery on convalenscence, contracture correction and recurrence rate.

To compare treatment of secondary Dupuytren*s contracture by standard limited (dermo)fasciectomy and by the modified percutaneous release combined with fat grafting. We focus specifically on return to function and if applicable to return to work (…

A randomised, double-blind, placebo-controlled,
multicentre prospective dose-finding Phase II/III study
with atacicept given subcutaneously to subjects having
recently experienced a flare of systemic lupus
erythematosus (SLE)

PRIMAIRYThe primary objective of this trial is to evaluate the efficacy of atacicept compared to placeboin preventing new flares in subjects with SLE.SECONDARYSecondary objectives of the trial are:• To evaluate the safety and tolerability profile of…

A prospective clinical study on the efficacy of collagenase clostridium histolyticum (CCH) injections in the thumb and first web space contractures in Dupuytren*s Disease

To evaluate the effectiveness of CCH as treatment for Dupuytren*s contracture in the thumb and first web space by assessing pre- and post treatment extension deficit and adduction contracture.

Effects of bosentan in a homogeneous population of SSc subjects with an early or active SSc nailfold capillaroscopic pattern

Primairy objective:- Evaluate the effect of bosentan on the blood flow in the hands from baseline to 12 weeks, measured by laser Doppler imaging, in SSc subjects with an early or active SSc pattern, measured with nailfold capillaroscopy (NFM), with…

The treatment of recurrent inguinal hernias after posterior repair

The aim of this study is to evaluate the safety and the outcomes of laparoscopic correction of a recurrent inguinal hernia after previous repair.

Long-term functional outcomes of ORIF for Intra-Articular Distal Radius Fractures

The aim of this project is to assess objective and subjective functional long-term outcome of patients with intra-articulair distal radius fractures treated with open reduction and internal fixation (ORIF). This will be done by standardized…

Evaluation of a tailored psychological intervention as component of multidisciplinary treatment for patients with Systemic Sclerosis and elevated levels of distress

The aim of the present study is to evaluate the efficacy of a protocol for cognitive behavioral treatment (CBT) of psychological distress as a component of multidisciplinary treatment in SSc on psychological distress.

sexual function in female systemic sclerosis

HypothesisSexual function in female systemic sclerosis patients is impaired as a result of fibrosis of the genital tract, fatigue, chronic pain, Raynaud*s phenomenon and contractures. AimThe aim of the study is to investigate sexual function and its…

The Effects of Epidermal Growth Factor Receptor (EGFR) Inhibition on Pulmonary Arterial Hypertension Associated with Systemic Sclerosis
A phase II controlled open-label safety and efficacy study.

The first objective is to evaluate the safety of cetuximab in patients with scleroderma associated PAH. The secondary objective is to assess efficacy.

Solis (PEEK) versus Solis (PLLA) resorbable cage for anterior cervical discectomy with fusion - Controlled randomized clinical outcomes study

The objective of this study is to compare short- and long-term surgical and clinical outcomes of patients with chronic neck pain and neck disability due to a single-level spinal disorder that undergo Anterior Cervical Discectomy followed by…

A pilot randomized controlled trial comparing the effect of a percutaneous and lipofilling technique in patients with a primary Dupuytren*s contracture with standard fasciectomy surgery on convalescence, contracture correction and recurrence rate.

To compare treatment of primary Dupuytren*s contracture by standard limited (dermo)fasciectomy and by the modified percutaneous release combined with fat grafting. We focus specifically on return to function and if applicable to return to work (…

The Ehlers-Danlos syndrome and regional anesthesia

Aim of this study is measuring the effects of locoregional anaesthesia in EDS patients and comparing these effects with those in a healthy control group. The results of this study can be used to make a more valid choice for the type of anaesthesia…

Double blind, placebo controlled study Tacrolimus versus Emmolient in localized scleroderma

The primary objective of this study is to assess whether tacrolimus is effective for the treatment of morphea.

A Multi-Center, Open label, Repeated Dose Range Finding Study to Evaluate the Safety, Tolerability, Immunogenicity, Pharmacokinetics and Efficacy of an Anti-IL-1β Monoclonal Antibody (ACZ885) Given Subcutaneously in Pediatric Subjects with Active Systemic Juvenile Idiopathic Arthritis (SJIA)

• Evaluation of the safety, tolerability and immunogenicity of subcutaneous (s.c.) administration of ACZ885 in pediatric subjects with SJIA.• Assessment of the initial efficacy profile (% responder to treatment and time to relapse) according to the…