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A Randomized, Double-blind, Active-controlled Study to Evaluate the Efficacy and Safety of Denosumab Compared With Risedronate in Glucocorticoid-treated Individuals

The primary objective in the glucocorticoid-continuing subpopulation of men and women treated with chronic glucocorticoid therapy (>= 7.5 mg daily prednisone or its equivalent for >= 3 months and are planning to continue treatment for…

Multi-centre, randomized, double-blind, parallel-group study evaluating the effect of Fluticasone Furoate/ Vilanterol (FF/VI) Inhalation Powder once daily compared with Vilanterol (VI) Inhalation Powder Once Daily on Bone Mineral Density (BMD) in subjects with Chronic Obstructive Pulmonary Disease (COPD) (HZC102972)

Effect on bone mineral density.

A Phase 3, Randomized, Double-blind Active-controlled Study
Evaluating Momelotinib vs. Ruxolitinib in Subjects with Primary
Myelofibrosis (PMF) or Post-polycythemia Vera or Post-essential
Thrombocythemia Myelofibrosis (Post-PV/ET MF)

The primary objective of this study is:* The primary objective of this clinical trial will be to determine the efficacy of MMB compared with ruxolitinib as measured by splenic response rate at Week 24 (SRR24).The secondary objectives of this study…

A Multicenter, International, Randomized, Double-blind, Alendronate-controlled Study to Determine the Efficacy and Safety of Romosozumab in the Treatment of Postmenopausal Women With Osteoporosis

To assess the effect of AMG785 treatment for 12 months followed by alendronate treatment compared with alendronate on the incidence of clinical fracture and new vertebral fracture.

The effectiveness of Pulsed Electromagnetic Field in the treatment of medial tibial stress syndrome: a pilot study.

Primary Objective: - Determine the effectiveness of a treatment with pulsed electromagnetic field therapy in patients with medial tibial stress syndrome (MTSS).Secondary Objective(s): - Determine the feasibility of the study design.- Determine the…

A multi-centre randomised double blind, placebo and active controlled parallel group study to investigate efficacy and safety of ONO-5334 in post menopausal women with osteopenia or osteoporosis.

The objective of this study is to investigate if use of ONO-5334 has a more positive effect on bone density and biochemical markers of bone turnover than Alendronate (a bisphosphonate) and placebo.

A Randomized, Double-Blind, Multicenter Study of Denosumab Compared with Zoledronic Acid (Zometa) in the Treatment of Bone Metastases in Men with Hormone-Refractory Prostate Cancer.

To determine if denosumab is non-inferior to zoledronic acid (Zometa) with respect to the first on-study occurrence of a skeletal-related event (SRE) in men with hormone-refractory prostate cancer and bone metastases.

A proof-of-concept study of SB-751689 in male and female with a fractured distal radius.

To evaluate the effects of SB-751689 on the time to radiographic healing, defined as the interval in days between the occurrence of the radial fracture and the time of complete bridging and/or disappearance of fracture line at 3 of the following 4…

A phase 1 double blind, placebo controlled study of ALX-0141 single dose subcutaneous administration in healthy post-menopausal women

- to determine the maximum tolerated dose (MTD) and/or biological effective dose (BED) after single s.c. administration of ALX-0141 - to determine the safety and tolerability of escalating single doses of ALX-0141 in healthy postmenopausal women

Efficacy of post-operative pain management with intralesional ropivacaine after subacromial decompression

The researchquestions of this study are:1. What is the efficacy of treatment of postoperative pain after subacromial decompression with a subacromial catheter with ropivacaine versus placebo?2. What are the differences in costs per patient and in…

Reduction of Bone Morbidity using Oral Bisphosphonate in Fibrous Dysplasia of Bone

To evaluate the effect of the bisphosphonate risedronate (together with vitamin D and calcium or vitamin D calicum and phosphate in patients with renal phosphate wasting) on bone pain and the evolution of osteolytic bone lesions in patients with FD.

A Randomized, Double-Blind, Multicenter Study of Denosumab Compared With Zoledronic Acid (Zometa®) in the Treatment of Bone Metastases in Subjects with Advanced Breast Cancer

To determine if denosumab is non-inferior to zoledronic acid (Zometa) with respect to the first on-study occurrence of a skeletal-related event (SRE) in subjects with advanced breast cancer and bone metastases.

A randomised controlled trial, comparing Surgical Decompression with an Interspinous Implant in patients with Intermittent Neurogenic Claudication caused by Lumbar Stenosis.

Primary objective is to demonstrate that the effectiveness of thesurgical intervention with Coflex is equivalent to surgical decompression without fusion after 1 year after surgery.Secundary objectives are to demonstrate that surgical intervention…

A randomised blinded comparison of surgical intervention with the X STOPPK® interspinous process decompression versus surgical decompression for patients with intermittent neurogenic claudication caused by lumbar stenosis

Primary objective is to demonstrate that the effectiveness of thesurgical intervention with X STOPPK is equivalent to surgical decompression without fusion after 1 year after surgery.Secundary objectives are to demonstrate that surgical intervention…

A Randomized, Double-Blind, Multicenter Study of Denosumab Compared With Zoledronic Acid (Zometa) in the Treatment of Bone Metastases in Subjects with Advanced Cancer (Excluding Breast and Prostate Cancer) or Multiple Myeloma

To determine if denosumab is non-inferior to zoledronic acid with respect to the first on-study occurrence of a skeletal related event (SRE) in subjects with advanced cancers and bone metastases (or lytic bone lesions from multiple myeloma).SRE is…

Pamidronate for pain in adult chronic nonbacterial osteitis (PAM-CNO): a randomized, double-blind, placebo-controlled trial

This study has been transitioned to CTIS with ID 2023-510309-16-00 check the CTIS register for the current data. The primary objective to demonstrate that in CNOpatients with pain 3-monthly treatment with pamidronate will result in significant…

Phase 3 Randomized, Placebo-Controlled Study to Assess Safety, Tolerability, and Efficacy of Garetosmab in Patients with Fibrodysplasia Ossificans Progressiva

This study has been transitioned to CTIS with ID 2023-508350-26-00 check the CTIS register for the current data. Primary ObjectiveThe primary efficacy objective of the study is to assess the effect of garetosmab (10 mg/kg) versus placebo on the…

A Randomized, Blinded, Placebo-controlled, Phase 2 Study of INBRX-109 in Unresectable or Metastatic Conventional Chondrosarcoma

This study has been transitioned to CTIS with ID 2024-517528-20-00 check the CTIS register for the current data. Primary objective:• To evaluate the anticancer efficacy of INBRX-109 in the intention-to-treat (ITT) population as measured by…

Phase III, pivotal, multicentre, randomised, double-blind controlled Study to evaluate the Efficacy and Safety of Autologous Osteoblastic Cells (PREOB®) Implantation in Early Stage Non Traumatic Osteonecrosis of the Femoral Head.

To determine the efficacy and safety of PREOB®, a proprietary population of autologous bone-forming cells, in the treatment of early stage non-traumatic osteonecrosis of the femoral head.