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*Alternative approaches to collect autogenous bone during implant site preparation: A clinical study*

The primary objective of the present study is: 1) To compare the amount, viability, nature and osteogenic potential of bone autograft collected with two different approaches: a) bone chips collected from the Camlog® drill flukes with aqueous…

Cervical spine movement, before and after anterior cervical discectomy (ACD).
ACD, pure intervertebral discectomy (1) compared to intervertebral discectomy followed by implantation of an intervertebral disc prosthesis (2) in patients with a radicular syndrome. A randomised study

Objective of the study is to verify whether the movement pattern after anterior cervical discectomy normalises, in case of implantation of a cervical disc prosthesis.

Prospective comparison in new challenging gait and balance tasks in female adolescents with idiopathic scoliosis before and following corrective spinal fusion

The aim of the present study is to use a more complete analysis of spinal motion (using a 3D multi-segment spine model) and to introduce challenging gait tasks which can optimally reveal the compensation strategies of the spine. Furthermore, static…

Treatment of Sever's Disease:
A Therapeutic Randomized Clinical Trial
Wait and See versus Orthotic device versus Physical Therapy

The goal of this trial is to find the best available conservative treatment, based on subjective pain scores, for children with Sever*s disease. Our primary objective is to score the possible decrease of pain experienced by the subjects. This will…

Cost-effectiveness of nerve root decompression according to Gill versus instrumented fusion in the treatment of spondylolytic spondylolisthesis; a multicenter prospective randomised trial.

The Sciatica-Gill trial is a randomised cost-effective study about nerve root decompression according to Gill versus instrumented fusion in the treatment of patients with radicular legpain or neurogenic claudication due to spondylolytic…

The use of Progentix TCP (beta-tricalciumphosphate) as a bone substitute in defects originated from curettage of benign bone tumors

In patients with benign bone tumors, the defect originated from curretage of the tumor, will be filled with Progentix TCP. The bone regenerative capacity of Progentix TCP will be compared to the capacity of autologous bone (the golden standard).…

A Randomized, Double-Blind, Multicenter Study of Denosumab Compared with Zoledronic Acid (Zometa) in the Treatment of Bone Metastases in Men with Hormone-Refractory Prostate Cancer.

To determine if denosumab is non-inferior to zoledronic acid (Zometa) with respect to the first on-study occurrence of a skeletal-related event (SRE) in men with hormone-refractory prostate cancer and bone metastases.

A proof-of-concept study of SB-751689 in male and female with a fractured distal radius.

To evaluate the effects of SB-751689 on the time to radiographic healing, defined as the interval in days between the occurrence of the radial fracture and the time of complete bridging and/or disappearance of fracture line at 3 of the following 4…

A phase 1 double blind, placebo controlled study of ALX-0141 single dose subcutaneous administration in healthy post-menopausal women

- to determine the maximum tolerated dose (MTD) and/or biological effective dose (BED) after single s.c. administration of ALX-0141 - to determine the safety and tolerability of escalating single doses of ALX-0141 in healthy postmenopausal women

A Feasibility Study on the use of Percutaneous Instrumentation for less invasive surgery of Scoliosis Deformity in Children with Neuromuscular Disease.

To test the surgical feasibility of the less invasive percutaneous pedicle screw instrumentation system for the treatment of children with a so called "hypotonic" scoliosis. Additionally, postoperative pain reduction and a reduced hospital…

Vertebroplasty versus radiotherapy as palliative treatment of vertebral metastases of multiple myeloma (M. Kahler)

Compare vertebroplasty with radiotherapy regarding costs and effectivity in treating pain, restoring mobility, and improving quality of life.

Displaced midshaft fractures of the clavicle: non-operative treatment versus Synthes ® plate fixation. A multi-centre randomised controlled trial in the Netherlands.

Results of recent trials suggest that operative treatment with locking plate fixation results in better functional outcomes than non-operative treatment. Because more patients were lost to follow-up than anticipated in the main randomised trial,…

Efficacy of post-operative pain management with intralesional ropivacaine after subacromial decompression

The researchquestions of this study are:1. What is the efficacy of treatment of postoperative pain after subacromial decompression with a subacromial catheter with ropivacaine versus placebo?2. What are the differences in costs per patient and in…

A clinical, prospective feasibility study to assess the effectiveness and safety of micro-structured TCP granules as a bone augmentation material in sinus floor elevation procedures.

The primary objective is to determine whether micro-structured TCP granules provides sufficient bone volume as basis to insert endosseous dental implants in a two staged sinus floor elevation technique by benefiting from the clinical handling…

Reduction of Bone Morbidity using Oral Bisphosphonate in Fibrous Dysplasia of Bone

To evaluate the effect of the bisphosphonate risedronate (together with vitamin D and calcium or vitamin D calicum and phosphate in patients with renal phosphate wasting) on bone pain and the evolution of osteolytic bone lesions in patients with FD.

Surgical Treatment of Unicondylar Distal Humerus Fractures, Fractures Patterns, Surgical Technique and Outcome after 10-30 Years.

We propose a protocol to invite patients with unicondylar fractures identified from the AMC database to return for evaluation and radiographs in order to collect long term (>10 years) data regarding the outcomes of these rare fractures.

A Randomized, Double-Blind, Multicenter Study of Denosumab Compared With Zoledronic Acid (Zometa®) in the Treatment of Bone Metastases in Subjects with Advanced Breast Cancer

To determine if denosumab is non-inferior to zoledronic acid (Zometa) with respect to the first on-study occurrence of a skeletal-related event (SRE) in subjects with advanced breast cancer and bone metastases.

A randomised controlled trial, comparing Surgical Decompression with an Interspinous Implant in patients with Intermittent Neurogenic Claudication caused by Lumbar Stenosis.

Primary objective is to demonstrate that the effectiveness of thesurgical intervention with Coflex is equivalent to surgical decompression without fusion after 1 year after surgery.Secundary objectives are to demonstrate that surgical intervention…

A randomised blinded comparison of surgical intervention with the X STOPPK® interspinous process decompression versus surgical decompression for patients with intermittent neurogenic claudication caused by lumbar stenosis

Primary objective is to demonstrate that the effectiveness of thesurgical intervention with X STOPPK is equivalent to surgical decompression without fusion after 1 year after surgery.Secundary objectives are to demonstrate that surgical intervention…

A Randomized, Double-Blind, Multicenter Study of Denosumab Compared With Zoledronic Acid (Zometa) in the Treatment of Bone Metastases in Subjects with Advanced Cancer (Excluding Breast and Prostate Cancer) or Multiple Myeloma

To determine if denosumab is non-inferior to zoledronic acid with respect to the first on-study occurrence of a skeletal related event (SRE) in subjects with advanced cancers and bone metastases (or lytic bone lesions from multiple myeloma).SRE is…