88 results
The aim of this study is to evaluate the long-term imaging and functional outcomes of overuse injuries of the wrist in (former) athletes.
The aim of the current project is to evaluate the long-term effects of a) a pragmatic lifestyle intervention aimed at weight loss and b) a 30-month placebo-controlled intervention with glucosamine sulphate on the development of knee osteoarthritis…
Objective: We want to extend our understanding of the disease aetiology by performing a small pilot study that incorporates other immunologic sites involved in the disease (the skin and the microbiome) while additionally strengthening our disease…
PRIMARY OBJECTIVETo identify the cellular mechanism behind early antidrug antibody (ADAb) production related to humoral responses within first 3 months of BP treatment.SECONDARY OBJECTIVES- To identify the affinity maturation process in ADAb…
The main objective of the study is to document cardiovascular dysfunction found in rheumatoid arthritis and gout patients using cardiac imaging techniques echocardiography and cardiac MRI.
In one FOA family we have detected a deleterious mutation in a compelling gene which co-segregates with the FOA phenotype in the family. This mutation is, therefore, is likely to be causal to the early onset OA. The objective of the study is:a) To…
Aim of this study is to obtain synovial tissue and synovial fluid, from 80 patients with non-septic, inflammatory knee arthritis undergoing routine arthroscopy of the knee and analyze inflammatory factors influencing osteoclast and osteoblast…
The aim of the study is to evaluate whether these three genetic characteristics are able to predict the susceptibility to joint damage in haemophilia patients. Therefore we want to determine the association between the progression of radiographic…
PRIMARY OBJECTIVE• To find early bio-markers within 3 months of the treatment with biopharmaceuticals (BP) able to predict immunization against BP within the first year of treatment.SECONDARY OBJECTIVES• To analyze the correlation between…
To investigate the effect of tourniquet application on the coagulation system in patients undergoing a knee arthroscopy. A finding of more prominent activation of the coagulation system with tourniquet use than with non-use will create an important…
To determine whether nonspecific triggering of monocytes is associated with different epigenetic programming and expression of pro-inflammatory cytokines in clinically suspect arthralgia and in RA.
To evaluate the presence of subclinical inflammation in painful joints in ACPA+ patients without clinical synovitis using MRI
Previous studies [10] have proposed that cartilage degeneration due to obesity could be caused by changes in the joint kinematics during ADL that shifts the loading applied to cartilage. Such a shift may cause regions of cartilage to become newly (…
To identify intraarticular parameters related to the initiation and course of development of articular cartilage lesions after knee trauma.
The primary objective in this study is to detect the presence of supra-spinal central sensitization in patients with chronic neck pain secondary to cervical facetal arthropathy. We aim to show this by comparing the pressure-pain thresholds (PPT; the…
- To investigate whether increased arm moment loading (with a constant exerted abduction force) in healthy controls leads to a relatively larger increase in deltoid muscle activation as compared to increase in supraspinatus muscle activation.- To…
Primary Objective: To investigate which underlying muscle properties can explain (expected) differences in strength between subjects with and without OA, and how muscle strength, voluntary activation and fatigability are related to function.…
The main hypothesis is that circulating inflammatory mediators are the main causative factor for the emergence of generalized osteoporosis in patients with Rheumatoid Arthritis (RA). 1.Does the serum of patients with active RA, containing…
The objective of this study is to investigate whether decreased variability in trunk-rotations during gait in CLBP patients can be attributed to stronger cognitive regulation and/or increased co-contraction of trunk musculature.
By means of the administration of a visual search task, an associative learning task, and an antisaccade task, we aim to resolve the primary research question whether a painful hand (more than a non-painful hand) positioned nearby a visual stimulus…