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Study Protocol Title: A Prospective, Open-Label, Multicenter Pivotal Study to Evaluate the Safety and Efficacy of GelrinC® for the Treatment of Symptomatic Articular Cartilage Defects of the Femoral Condyle: A Comparison to Historical Control Microfracture

To demonstrate the superior clinical efficacy of GelrinC on pain and function for the treatment of symptomatic focal articular cartilage defects of the femoral condyle in comparison to microfracture historical control at 24 months post-surgery.

Dynamic Intraligamentairy Stabilisation of the acute torn anterior cruciate ligament, a multicenter prospective cohort study.

To assess the efficacy of treatment of acute ACL ruptures with the Ligamys device.

comparison between different types of gastrocnemius-soleus stretching in the treatment of plantar fasciitis: posterior night splint, soft night splint of a custom-made cast.

To assess the clinical outcome and evaluate the effectiveness after treatment of plantar fasciitis with a posterior tension night splint (Pro Orthics), soft night splint (Strassbourg sock) or custom made cast for the treatment of plantar fasciitis…

The effect of coblation treatment on knee cartilage quality in patients with meniscal lesions and cartilage loosening of the knee

Primary Objective: To study the in vivo effect of coblation treatment on knee cartilage quality in patients with meniscal lesions and partial cartilage loosening of the knee.Secondary Objective: To study the relationship between knee cartilage…

A Phase 3, Randomized, Double-blind, Placebo and Adalimumab-controlled Study to Evaluate the Efficacy and Safety of Filgotinib in Subjects with Active Psoriatic Arthritis Who Are Naïve to Biologic DMARD Therapy

The primary objective of this study is:* To evaluate the effect of filgotinib compared to placebo in active psoriatic arthritis (PsA) as assessed by the American College of Rheumatology 20% improvement (ACR20) response at Week 12Secondary objectives…

Additional effect of hydrolysed collagen/vitamin C in exercise treatment for Patellar Tendinopathy (Jumper*s knee); a randomized controlled trial

The primary aim of this RCT is to evaluate whether the use of oral supplementation of hydrolysed collagen/vitamin C in addition to usual care (education, load management and PTLE) is superior to usual care and placebo on VISA-P score after 24 weeks…

Surgery and exercise versus exercise only for chronic patellofemoral pain syndrome: a randomised controlled trial.

Zie het onderzoeksprotocol 2: "Objectives".

A multi-center, pivotal, non-randomized, prospective, open-label study to evaluate the safety and performance of the Hy2Care Injectable Hydrogel for the repair of cartilage defects in the knee.

Primary objectives:Safety:To demonstrate the safety of the investigational device in 10 subjects at 3 months post-surgery.Safety cohort data will be pooled with the performance cohort data, to measure the performance and safety of the…

Functional Outcome of Vanguard XP vs CR: a single centre randomized controlled trial using three dimensional fluoroscopic analysis

The primary objective is to compare the Vanguard XP with a CR TKA in terms of kinematics during functional tests using 3D fluoroscopy. The secondary objective is to compare both TKAs in terms of 3D migration of the prosthesis up until 2 years post-…

Repair versus reconstruction of proximal anterior cruciate ligament tears

The objective of this prospective randomized controlled trial is to compare the outcomes of arthroscopic primary repair of proximal ACL tears with the current gold standard of ACL reconstruction.

Randomized controlled trial on clinical outcomes and safety of Instant MSC Product accompanying Autologous Chondron Transplantation (IMPACT) for focal articular cartilage lesions of the knee

This study has been transitioned to CTIS with ID 2024-514612-27-01 check the CTIS register for the current data. The primary objective is to measure the level of clinical improvement and quality of life at 3, 6 and 9 months compared to…

Multifactorial Approach Training for Anterior Shoulder Instability in patients undergoing arthrosopic bankart repair: a randomized controlled trial

In this research, we are comparing two distinct physiotherapy treatments as post-operative care following shoulder arthroscopy (Bankart repair). Our aim is to gain a better understanding of how to provide optimal post-operative care for patients and…

Lateral ligament repair for ankle instability protected with internal bracing. A multicenter, randomized controlled trial.

To evaluate if patients with chronic, recurrent lateral ankle instability who are treated with surgical lateral ankle ligament repair protected with an internal brace, have significant better ankle function after surgery compared to patients treated…

Which patient with an anterior cruciate ligament rupture will need a surgical reconstruction?*

To evaluate the cost-effectiveness of a treatment algorithm for patients with a complete ACL rupture compared to current used treatment strategy, over a follow-up period of 2 years. With the treatment algorithm faster recovery of functional outcome…

CAsting and REhabilitation for osteochondral lesions of the talus in the skeletally immature: a prospective comparative observational study

The aim of this study is to improve the conservative management of OCLs of the talus in the skeletally immature due to the comparison of two different conservative strategies. An optimal conservative treatment can result in a better quality of life…

A Prospective and Consecutive Clinical Evaluation of Soft Tissue Regeneration*s L-C Ligament® in
Primary ACL Reconstruction

The primary objective of this study is to evaluate the safety of the L-C Ligament in primary ACL reconstruction. The secondary objectives of this study are to evaluate pain, function, and radiographic performance of the L-C Ligament in primary ACL…

Multicenter randomized controlled trial on nonoperative versus operative treatment for acute complete tears of the ulnar collateral ligament of the thumb: Cost-effectiveness and functional outcomes (MUSCAT-study)

The project aims to conduct a multicenter randomized controlled trial and cost-effectiveness analysis comparing operative and nonoperative treatment for complete UCL ruptures, including Stener Lesions. The project will take four years, from…

Effectiveness of corticosteroid injection in treatment of trigger fingers: a double blinded randomized clinical trial

We hypothesize that Kenalog-40, Kenalog-10 and Depo-Medrol 40 mg/ml have a different effectiveness in treating trigger fingers in both primary as secondary outcomes.

L-C LIGAMENT® VERSUS HAMSTRING AUTOGRAFT FOR PRIMARY ACL RECONSTRUCTION: A PROSPECTIVE, RANDOMIZED CONTROLLED TRIAL
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To assess performance and safety of L-C Ligament® against autograft surgery with hamstring tendon for primary ACL reconstruction.

Mid-term follow-up of a randomized controlled trial comparing ultrasound-guided double percutaneous needling versus high-energy extracorporeal shockwave therapy in the treatment of calcific tendinitis of the rotator cuff.

The objective of this study is to analyse the longterm effectiveness of high-energy ESWT and ultrasound-guided needling in patients with symptomatic calcific tendinitis of the rotator cuff. The assessment parameters are the functional outcome, pain…