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Twente Lower Extremity Model safe: Improving safety and predictability of complex musculo-skeletal surgery using a patient-specific navigation system.

Primary objective: To create and validate healthy-subject-specific musculo-skeletal models of the lower extremity. We will also develop a new method using the Positron Emission Tomography (PET) technique that can be used to validate musculo-skeletal…

A randomised multicenter study comparing anterior cervical discectomy with or without interbody fusion and arthroplasty in the treatment of cervical disc herniation.

To show whether Active C disc prosthesis is more effective than anterior discectomy with or without interbody fusion 1 year after surgery. Moreover, the incidence of adjacent disc degeneration will be evaluated 5 years after surgery.

Assessment of intraoperative embolism during spinal surgery
with transesophageal echocardiography.

To assess the incidence and severity of embolic events during spinal instrumentation surgery with intraoperative transesophageal echocardiography monitoring.

Magnitude and time course of physical deconditioning in severely injured or critically ill patients; A clinimetric evaluation

Before a countermeasure or training can be developed to counteract physical deconditioning it is important to investigate more in detail the magnitude and time course of physical deconditioning and to investigate which outcome measure is most…

The PLUS Study: Preventing Lumbar disc surgery

The primary objective of this study is to assess the effectiveness and cost-effectiveness in terms of the number of surgeries prevented of a combination therapy versus usual care.The secondary objective of this study is to assess the effectiveness…