24 results
The purpose of this study is to investigate the value of postoperative cryotherapy on subjective patients-reported pain; shoulder function and quality of life in patients operated for SAPS .
Primary Objective: The primary aim of this study is to determine the degree of patient satisfaction and assess objectively the clinical outcome at a minimum of five years follow-up after surgical intervention. Secondary Objective(s): The secondary…
PRIMARY OBJECTIVEThe primary objective of the study will be to determine the efficacy of 12 weeks of nilotinib treatment as measured by the non progression rate (Complete response + Partial Response + Stable disease according to Response Evaluation…
Open surgical treatment for calcified insertional Achilles tendinopathy; a long-term follow-up study
In this study we will assess the results of the operative treatment in the AMC using three questionnaires. In addition, to determine whether radiography is also useful as a diagnostic tool after a successful treatment, a conventional lateral…
A pragmatic randomized single blinded clinical trial was designed with the objective to compare the use of customized insoles, night splints and a barefoot technology shoe for the treatment of plantar heel pain syndrome.
The objective of the study is to standardize portal placement in endoscopic calcaneoplasty, thereby taken into account the three different foot shapes, cavus, valgus and normal feet. Primarily the FOPP- device needs to be validated. If found valid,…
To get an impression concerning the patient flow, degree of patient drop-out, required time for the research workers, financial costs, logistical problems and the effectiveness of treatment with tape.
Primary objective:To determine the hepcidin levels before, 2, 4, 8 and 24 hours after the administration of anti-IL-6R in patients with RA.Secondary objective:To determine the levels of Iron, transferrin , (calculation of transferrin saturation),…
The primary objective of this endpoint study is to evaluate the safety of tofacitinib at two doses versus TNFi; the co-primary endpoints are adjudicated major adverse cardiovascular events (MACE) and adjudicated malignancies excluding non-melanoma…
The objectives of this study are to evaluate the safety, efficacy, and pharmacokinetics (PK) of AMB-05X in the treatment of tenosynovial giant cell tumor (TGCT)
This study has been transitioned to CTIS with ID 2024-517865-17-00 check the CTIS register for the current data. We hypothesize that the timing of treatment in IA, also known as chronotherapy, matters and that the efficacy of tofacitinib XR depends…
This study has been transitioned to CTIS with ID 2024-518966-28-00 check the CTIS register for the current data. The primary goal of this study is to investigate the effects of belimumab on the composition of lymph nodes and the inflamed synovial…
Lifestyle intervention programs reduce inflammatory activity and might, therefore, be of added value in the management of patients with an inflammatory arthritis. Therefore, the aims of this randomized controlled trial are: 1. To compare the…
To assess the efficacy of adding subcutaneous TCZ to csDMARD therapy compared with adding oral prednisone (10 mg daily).
Primary:- To evaluate the progression free survival in patients who are treated with ramucirumab in combination with gemcitabine and docetaxel compared with gemcitabine and docetaxel in pediatric and young adult patients with SS.Secondary:- To…
Primary Objective: To compare the effectiveness of the administration of secukinumab to standard care in newly diagnosed Psoriatic Arthritis patients on the ACR50 response at 6 months. Secondary Objectives: To compare effectiveness at 6 and 12…
Primary:To estimate the treatment effect of emactuzumab on objective response rate (ORR) by 6 months from initiation of therapy in the blinded phase compared to placeboSecondary:the effect of emactuzumab on clinical outcome assessments (COAs) for:o…
Obtain safety and efficacy data for the investigational drug AMB-05X in the treatment of tenosynovial giant cell tumor (TGCT)
Primary- Phase 1: To determine the recommended dose (RD) of cabiralizumab in patients with pigmented villonodular synovitis (PVNS)/diffuse type tenosynovial giant cell tumor (dt-TGCT)- Phase 2: To estimate the objective response rate (ORR = CR+PR)…
This study has been transitioned to CTIS with ID 2024-511530-12-01 check the CTIS register for the current data. We hypothesize that treatment of RA can be individualized by taking into account the presence of autoantibodies and quick response to…