24 results
Primary Objective: (1) To study the efficacy of low volume high-intensity resistance training for improving glycemic control in patients with T2DM. Secondary Objectives: (2) To study the feasibility of low volume high-intensity resistance training…
To study the effect of individualized nutritional counselling compared to usual nutritional care on cross-sectional muscle area in patients with stage IV colorectal cancer during first-line chemotherapy. Secondary, effect on total lean body mass,…
The primary objective of this study is to assess the efficacy of the use of motivational interviewing to improve adherence to wearing prescribed footwear in diabetic foot patients. Secondary objectives are to assess the feasibility of applying…
The objective of the study is to gain insight in the role of endogenous GLP-1 on food-stimuli related CNS satiety and reward responses and the alterations between lean and obese-T2DM individuals. Also, to gain information about treatment with a GLP-…
Primary Objective: To assess immediate and long-term effects of Mindfulness-based Cognitive Therapy (MBCT) and Cognitive Behavioral Therapy (CBT) in reducing depressive symptoms in patients with diabetes. Regarding immediate effects, we expect that…
The primary objective of this study is to evaluate tolerance of a new high-energy high-protein oral nutritional supplement compared to a commercially available high-energy high-protein oral nutritional supplement in elderly subjects in need of oral…
The aim of the proposed study is to evaluate the effect of daily consumption of 400 gram strawberries as smoothies during 2 weeks on markers of endothelial function, inflammation and oxidative stress.
To confirm the efficacy of liraglutide as adjunct to insulin treatment on glycaemic control, and toconfirm the superiority of liraglutide treatment compared to placebo, both adjunct to insulintreatment, with regard to reduction in daily insulin dose…
Objective: The primary objective is to evaluate whether distal LRYGB (DLRYGB) is superior in terms of %EWL after one year follow-up compared to standard LRYGB (LRYGB). Secondary objectives are to evaluate effect on quality-of-life (QOL), cure /…
In this RCT we combine cognitive behavioural therapy (CBT) with a maintenance contract and a specific diet (very low calorie diet), to obtain and maintain favourable effects on weight and risk profile over the long term.
The purpose of the study is to confirm the skin test results in patients based on results of the control population of healthy volunteers never exposed to taspoglutide or any product with a similar mechanism of action.
The objectives of the present study are twofold:1 screening patients with diabetes type 2 for psychological risk factors and2 studying the effect of a self-management training on metabolic regulation in patients starting with insuline therapy
The present study examines an extended version of this intervention that aims to address more challenging self-management goals once patients have mastered the skills necessary to achieve relatively small improvements in their self-management. The…
The primary study objective is to investigate the contribution of peri-operative suppletion of bile to the preservation of bodyweight (expressed in kilograms).Secondary study objectives:1.To determine the contribution of peri-operative suppletion of…
The objective of the study is to investigate the glucose lowering potential and safety of continuation of Metformin during non-cardiac surgery, compared to discontinuation of Metformin 24 hours before surgery.
Primary* Evaluate the safety and tolerability of single- and multiple-ascending doses of ALN-GO1, respectively, in healthy adult subjects and in patients with PH1Secondary* Characterize the pharmacokinetics (PK) of ALN-GO1* Evaluate the…
Primary Objective: 1. To determine the effectiveness of a personalised, holistic 24-week digital lifestyle programme in achieving diabetes type 2 (T2DM) remission independence from blood glucose-lowering medications, in a Dutch population, in…
To investigate the effect of intraduodenal, intraileal and combined infusion of a combination of tastants versus infusion of placebo on food intake.
To investigate the effect of oral sham feeding of and intragastric delivery of quinine (a bitter agent) versus placebo on food intake.
Primary Objective: To evaluate the effects of LRYGB with subtotal gastrectomy (LRYGB+) as compared to standard LRYGB (LRYGB-) on striatal D2/D3 receptor availability and dopamine release as well as on whole brain serotonergic activity. Secondary…