150 results
The aim of this study is to determine whether subcutaneous administration of insulin detemir, as compared to NPH insulin, leads to a more pronounced effect on brain glucose metabolism and blood flow in brain regions associated with appetite…
To establish the presence of direct trans-intestinal cholesterol excretion (TICE) in humans by faecal recovery of i.v. administered 13C-cholesterol in patients with a total biliary obstruction. This is a so-called proof-of-concept study.
1. To determine the 10 year course and outcome of Anorexia Nervosa.2. To explore predictors of outcome in Anorexia Nervosa.
The purpose of the study is to standardize continuous glucose monitors for measuring blood glucose profiles during the day.
1. To include the patients* point of view in the characterization and description of the mucopolysaccharidoses; and to compare between the different types of mucopolysaccharidoses.2. To assess *health damage* at the moment of diagnosis, in order to…
In this study we will assess the effects of exenatide on cardiac metabolism and function in patients with T2DM and CHF. We will address the following hypothesis: exenatide improves global cardiac function in CHF patients with T2DM, by favorable…
The aim of this study is to develop and evaluate a patient-oriented treatment decision aid (PTDA) focussing on shared goal-setting and decision making, which is tailored to the needs and capacities of a heterogeneous group of patients with type 2…
The first aim of this study is to extend clinical knowledge on NPC. This has several reasons:1) The heterogeneous clinical presentation of NPC makes extensive clinical knowledge amongst physicians a prerequisite in preventing diagnostic delay.…
The objective of the study is to be able to determine the contribution of blood inorganic phosphate to the signal observed in skeletal muscle.
The objective of this study is to learn from young people with a chronic illness (diabetes or progressive muscular disease) who have found a balance between taking good care of their illness and having a good life. This study examines how these…
To identify eyes that show worsening and disease progression (progressor phenotypes). Primary ObjectiveTo identify *progressors* in retinal vascular disease and central retinal edema in type 2 diabetic patients with early NPDR, based on retinal…
In this study we want to investigate the effects of sustained hyperglycaemia and hypoxia on the hypoxic pulmonary vasoconstriction and hypoxic ventilatory response
The study has two objectives:1) Is chronic fatigue a clinically relevant issue in patients with DM type 1?Chronic fatigue will be considered a clinically relevant issue if:(a): the proportion chronically fatigued DM type 1 patients is at least 25%(b…
Hypotheses: - The five tastants (sour, sweet, salt, bitter and umami) each induce GI peptide release by human duodenal mucosa ex vivo. - The five tastants (sour, sweet, salt, bitter and umami) each induce GI peptide release by human ileal mucosa ex…
The presently proposed study aims to investigate the effects of different dairy products, which are frequently used in the Netherlands and not yet analyzed, on Glycemic Index and Insulin Index in humans. This will be investigated by analyzing…
The aim of this study is the collection of clinical data to develop and test calibration, filtering and prediction algorithms to be embedded in the so-called *smart sensor* for the enhancement of continuous glucose monitoring outcomes. In particular…
The presently proposed study aims to investigate how different feeding frequencies lead to differences in glucose and insulin metabolism in impaired glucose tolerant (IGT) men.
1. To determine the nature and time course of the energy sensing machinery during starvation in humans.2. To correlate systemic adaptations with changes at the cellular level.
To study whether the lower cholesterol absorption rates of the Dahlia-2a study were due to lower bioavailability of the oral D7-cholesterol tracer.
What is the difference in fractional cholesterol absorption, measured by means of the dual isotope method, between mildly hypercholesterolemic subjects with high plasma campesterol levels compared to subjects with low plasma campesterol levels?