87 results
Aim of this pilot study is to determine which intervention groups are feasible in a larger trial which aims to a compare postoperative pain and complication rates in moderate versus deep neuromuscular blockade, and normal versus low intra-abdominal…
The aim of this pilot study is to assess the effect of low intensity mastication training in patients with a mitochondrial disease on masticatory performance, efficacy, endurance, bite force and the feasibility of this training .
The primary objective of this study is to investigate the effects of classical conditioning with intranasal insulin on endogenous insulin and glucose levels in diabetes type-2 patients and healthy controls. Additionally, we will examine the effects…
To investigate the effect of oral sham feeding of and intragastric delivery of quinine (a bitter agent) versus placebo on food intake.
The primary aim of the study is to determine the incidence of perioperative hypovolemia in the elderly patient scheduled for major surgery, and how this relates to postoperative complications.
The objective of the study is to evaluate the (cost-)effectiveness of a stepped-care approach starting with HypoAware, compared with CGM in type 1 diabetes patients with an impaired awareness of hypoglycemia.
To assess the effects of intradialytic exercise and protein ingestion on amino acid loss into the dialysate and plasma total amino acid concentrations.
The aim of the proposed study is to screen for (pre)DM, an increased 10-year-risk of ASCVD, MetS and a high risk of OSAS in subjects with and without periodontitis. Consequently, the dental office will be evaluated as a suitable location for early…
The objective of this project is to study the effects of low levels of dietary AGEs in overweight subjects on insulin sensitivity, *-cell function, micro- and macrovascular function, and gut microbiota. The obtained insights can be used to attenuate…
We will study the cerebral glucose metabolism before, during and after surgery by sampling the cerebrospinal fluid (CSF) via the spinal catheter in patients undergoing thoracic surgery. Changes in cerebral glucose metabolism and activation of the…
To examine whether L-arabinose addition to a sucrose drink will lower glycaemic and insulinemic responses in people at increased risk of developing type II diabetes.
The primary objective of this study is to investigate to what extent hepatic fat oxidation can be stimulated by lowering hepatic glycogen content during a prolonged overnight fast. The secondary objective is to investigate whether reductions in…
To assess accuracy of ECGM vs FLFM in 25 subjects with diabetes before, during a 6 day mountainbike tour and after the tour in the Sierra NevadaTo assess the (differences in ) time in hypo-, normo- ,and hyperglycemia (expressed in minutes per day…
Purpose of this descriptive study is to gauge the feasibility of the Q1.6 app as platform to measure gout flares in real time. Primary research question: What is the perceived patients* value of thirty patients of app-based platform Q1.6 for…
To improve BP control and health related quality of life by offering a nurse-led patient-centred supportive intervention to people with T2DM who are objectively non-adherent to their antihypertensive medication and/or life style behaviour…
The primary objective is to evaluate in the two targeted populations (i.e. CD and self-reported NCGS subjects):1) the safety profile of BL NCC 2705 2) the gastro-intestinal (GI) tolerability of BL NCC 2705
Primary objective:To investigate the correlation between skeletal muscle phosphocreatine (PCr) on-kinetic at the beginning of exercise and CrAT protein abundance/activity in healthy young males characterized by a wide range of maximal aerobic…
The primary objective of the study is:* To demonstrate the reduction of low-density lipoprotein cholesterol (LDL-C) by evinacumab 15 mg/kg intravenously (IV) in comparison to placebo after 24 weeks in patients with homozygous familial…
Primary objective is the delta change in whole body insulin sensitivity upon Na-PB vs. placebo treatment. Secondary objectives are muscle mitochondrial oxidative capacity, muscle and liver fat content and energy metabolism.
Phase 1 (0 - 24 Weeks) Objective:To study the effect of DMR on glycemic and mechanistic endpoints24 weeks post-procedure in subjects with T2D.Phase 2 (24 - 48 Weeks) Objective:To study the effect of DMR on glycemic endpoints for assessment…