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A Phase 2, Multicenter, Randomized, Active-Controlled, Parallel-Group, Dose-Finding and Safety Study of Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2)/Calcium Phosphate Matrix (CPM) in Subjects With Decreased Bone Mineral Density.

Onset of effect of systemic therapy to enhance bone density (eg, bisphosphonates) is not immediate and may not adequately protect subjects with decreased bone density from fracture.Bisphosphonate therapy will typically require 2 to 3 years of active…

Calcium intake and osteoporosis in postmenopausal women with an intellectual disability

We examine whether the calcium intake from food in postmenopausal women with an ID suffice to the quantity calcium intake that is advised by the NHG-standard. If the conclusion of this study will be that the population is eating less calcium than is…

The effect of support by telephone on compliance with medication by osteoporosis patients using bisphosphonates objectivied by systematic control of serum bonemarkers

This study investigates to which degree osteoporosis patients taking weekly oral bisfosfonate medication are influenced by by three telephone support calls during the first year after starting this medication.To verify the results of patients` self…

Bone - MRI in Renal Insufficiency

The objective of this study is to assess the diagmostic accuracy of microMRI to detect ROD in children with ESRD and metabolic bone disease by oxalosis in patients suffering from oxalosis.

BONE MINERAL DENSITY IN PROSTATE CANCER PATIENTS TREATED WITH ANDROGEN DEPRIVATION THERAPY

To assess whether a change in BMD as detected big DXA (gold standard) is comparable with the decline measured by the achilles method

Suitability of the Dutch osteoporosis case-finding instrument, as a tool for vertebral fracture case-finding in a primary health care setting.

The aim of this study is to assess the sensitivity, specificity and predictive value of the Dutch osteoporosis case-finding instrument as a tool for vertebral fracture case-finding in a primary health care setting. Furthermore the impact of a…

Assessment of fracture healing by high-resolution peripheral quantitative computer tomography (HRpQCT) and bone strength analysis in standard care and after immediate administration of vitamin D.

Fracture healing groupPrimary outcome: to study the healing of distal radius fractures in terms of calculated bone strength based on the results of cortical and trabecular bone parameters using a novel HRpQCT technique (XtremeCT device, Scanco,…

Assessment of fracture healing by high-resolution peripheral quantitative computed tomography (HR-pQCT) and bone strength analysis in standard care and after immediate administration of calcium supplementation

The main objective is to compare the effect of immediate (or pre-existent) administration of daily calcium supplementation (1 Cacit bruisgranulaat *1000*: 1000 mg calcium) or two daily dosages of calcium + vitamin D (CaD® sachet 1000/880: 1000 mg…

A prospective, single-cohort, multicentre clinical investigation to evaluate the performance of
POROUS R3C ultrasound device for fracture risk prediction in middle-aged and elderly men
and women

Primary objectivesPart 1:• To establish a corrected standardized gradient of fracture risk using the POROUS R3C ultrasound device based on prevalent fractures.Part 2:• To establish a corrected standardized gradient of fracture risk using the POROUS…