193 results
The primary objective of this study is to investigate the effect of lifestyle and dietary habits on outcomes in patients with type 2 diabetes mellitus.
The purpose of study Period 1 is to find out how much study compound, PF-07081532, is in your blood, urine, feces and exhaled air after you take a *radioactively-labeled" form of the study compound as a liquid that you drink. A radioactive…
The primary aim of the study is to improve microvascular endothelial health after 3 months expressed by the Microvascular Healt Index, using a non-invasive imaging technique, upon two different dietary interventions compared to the placebo. The…
A relationship can be identified between HbA1c levels and self-management and quality of life. It appears better self-management skills result in a larger improvement of HbA1c levels, and the other way around, getting control over HbA1c levels is a…
Primary Objective:To investigate whether arterial microcalcification (18F-NaF-PET detected) and macrocalcification (CT detected) are increased in patients with T2D who have macroalbuminuria as compared to patients with normoalbuminuria.Secondary…
To cure chronic wounds with fibrin treatment.
The aim of this research is twofold:1) Determining the functionality of the oxygen sensor in the neck (the glomus body or *carotid body* during the administration of glucose and insulin, a so-called euglycemic hyperinsular clamp.2) Validating a new…
The study investigates whether the glycemic response to standardized snacks differs within subjects between different times of the day. The study concerns a pilot for a future larger study of more complex aspects of the nutritional and physical…
The main objectives are:• To assess canagliflozin target (i.e. receptor) specific binding in vivo• To assess receptor occupancy of canagliflozin in vivo• To determine optimal scanning time in vivoTo explore the relationship between canagliflozin…
The purpose of this study is to evaluate the effect of high dose RAS-antagonists and beta-blocker treatment for the primary prevention of cardiac events in a population of patients with Type 2 diabetes mellitus (T2DM) with no evidence of a…
The primary objective of this study is to validate 31P-MRS as a non-invasive in vivo measure of mitochondrial function. Secondary objectives are to determine whether there is mitochondrial dysfunction in the heart of type 2 diabetic patients and to…
Evaluate the effect of the adjustable rocker, the self-adjusting insole, and a combination of both on in-shoe plantar peak pressures in patients with diabetes related neuropathy.
Primary Objective: Gain insight in the course of plasma phosphate and its (de-)regulators during DKA. Secondary Objective(s): Address the potential association and role of hypophosphatemia in oxidative stress / mitochondrial dysfunction / tissue…
With this proof-of-concept study, we will address i. differences in dopamine release in T2DM patients versus historical lean controls, ii. whether timed restoring of dopamine signalling improves dopamine release and iii. whether this reinstatement…
To demonstrate the noninferiority of insulin glargine 300 U/mLin comparison to insulin degludec 100 U/mL on glycemiccontrol and variability in participants with diabetes mellitus
Primary objective:* To investigate the consequences of (recurrent) hypoglycaemia on inflammatory responsesSecondary objectives:* To study the atherogenic consequences of (recurrent) hypoglycaemia* To study the molecular mechanisms involved in the…
The main objective of this study is to investigate if exercise training improves 24h rhythmicity in substrate metabolism in prediabetes subjects. Secondary objectives include linking 24h substrate metabolism to day-night differences in mitochondrial…
The purpose of this observational pilot study is to evaluate the extent to which the combined glucose, heart rate, blood pressure, and other outcome patterns, collected from wearables, are associated with the severity of micro- and macrovascular…
The main objective of the study is to determine the albuminuria lowering effect of the GLP1-RA exenetide, SGLT-2 inhibitor dapagliflozin and their combination in patients with type 2 diabetes and micro- or macroalbuminuria.Secondary objectives are…
1. To establish optimized and standardized approaches for the isolation and characterization of BOECs in control and diabetic patients.2. To test whether the phenotype of BOECs cultured from blood of diabetic patients are significantly different…