62 results
Aim is to establish the relation between plasma and tissue AGE levels and the severity of diastolic/vascular dysfunction and its relation with symptoms in patients with type 2 DM with and without CHF, and in patients with CHF without DM. Primary…
Primary Objective: In this study we investigate the adipose tissue depot-specific differences in adipocyte function and inflammation in patients with T2DM and subjects suffering from CVD compared to healthy subjects.Secondary Objective: Characterize…
The primary goal of this study is to te verify that it is possible to measure te concentrations of cytokines IL-1α, IL-1RA en IL-8 in the fluid of a blister that is applied tot the skin of healthy volunteers. using cantharidin. In the future we wish…
The primary goal of this study is to obtain basal knowledge about cytokine concentration in healthy volunteers, after pressure application. In the future we wish to use this knowledge for developing a method for:1. determining a patients risk of…
Identification of genetic risk factors for development of type 2 diabetes, diabetes related diseases and complications. Furthermore the examination of the relationship between genetic variation, biochemical factors, environmental factors (obesity…
Primary Objective: 1) To charaterize microbleeds and microinfarcts at 7T, and compare their prevalence in people with and without diabetes, with or without cognitive impairmentSecondary Objective(s): 2) To assess the relevance of the lesions in the…
Primary Objective: 1) To compare the prevalence en number of microbleeds at 7T between older people with and without DM2, and to relate the lesions to cognitive performanceSecondary Objective(s): 1) To characterize cerebral microinfarcts at 7T and…
The major research objective is:- to examine whether elevation of plasma FFAs results in cardiac lipid accumulation and whether this influences cardiac function negatively.Additional research objective: - to examine whether cardiac lipid content is…
The primary objective of the proposed study is to investigate the level of physical activity among lean and obese middle-aged individuals. We hypothesize that the level of physical activity among healthy (obese) subjects is higher than in patients…
Assessment of hepatic HSPG*s in NASH associated dyslipidemia in 8 subjects with DM2 associated NASH (insulin resistant, n=8) vs NASH in FHBL (non insulin resistant, n=8) and control subjects (hemochromatosis, n=8)
The primary goal of this study is to obtain basal knowledge about cytokine concentration in healthy volunteers, after pressure application. In the future we wish to use this knowledge for developing a method for confirming the hypothesis that in…
To assess at which level of glycemia the process of endothelial damage, represented by ROS formation and glycocalyx damage begins and to determine whether there is a glycemic threshold value for oxidative stress formation and glycocalyx damage. To…
To study the possible beneficial effect of simvastatin on accumulation of triglycerides in the myocardium of patients with DM2 and the effect on vessel wall thickness using magnetic resonance imaging and spectroscopy
What is the prevalence of ASB and incidence of UTIs during pregnancy in women with DM or GDM compared to pregnant women without diabetes? In addition, risk factors for ASB and UTIs, as well as consequences of ASB and UTIs will be investigated. These…
To evaluate the correlation between the findings from the explained non invasive vascular tools (CIMT, PWV, FMD and OPS imaging) with prevalent CVD in diabetic individuals.To evaluate the potential of non invasive vascular tools for identification…
The objective of the study is to gain new insights in the causes of a higher clopidogrel resistence in type II diabetes mellitus patients
In the current study we want to obtain fundamental insight in the role of insulin-mediated glycocalyx modulation as well as the effect of FFAs on this mechanism. We propose that increased levels of FFA degrade the glycocalyx and result in an…
1. The objective of this study is to aquire knowledge about the development of reactive hyperaemia and inflammatory responses of the skin after shear- force and pressure loading. We want to investigate if patients with diabetes type 2 will develop…
In this study we will investigate the intracellular metabolism and inflammatory state of CD14+ cells from blood and different adipose tissue depots in subjects with type 2diabetes mellitus compared to lean and obese healthy controls.
The primary objective is to identify additional genetic loci associated with skin fluorescence in patients with type 1 diabetes Mellitus. Secondary we want to assess if the identified loci are also associated to HbA1C, or if alternative loci are…