62 results
We aim to study the role of PVAT in regulation of vascular function, tissue perfusion and glucose uptake in muscle. We hypothesize that PVAT determines insulin-induced vasoreactivity when studied ex vivo and correlates with insulin-induced…
We aim to study the role of PVAT in regulation of vascular function, tissue perfusion and glucose uptake in muscle. We hypothesize that PVAT determines insulin-induced vasoreactivity when studied ex vivo and correlates with insulin-induced…
To investigate the effects of a short term (3 months) high protein (HP) diet compared to a low protein (LP) diet in T2D patients of Caribbean and Caucasian ethnic background with regards to gut microbiota composition and production of pro-diabetic…
In this study we will confirm that a microbial intervention based on capsules containing autologous (own) lyophilized faecal matter (LFMT), taken daily for 3 month has beneficial effects on residual beta cell function (C-peptide secretion upon MMT)…
To assess the uniqueness of diabetic cardiomyopathy (DCM) relative to other forms of cardiomyopathy using unsupervised clustering approaches based on deep phenotyping (clinical, imaging and biological) information. With the results of this study we…
Objective: 1. To investigate whether T1D individuals with preserved β-cell function exhibit a distinct gut microbial and circulating immune cell signature, leading to a reduced incidence of diabetes complications (CVD, nephropathy, neuropathy, and…
Primary objectives: 1.1) To investigate to what extent the different functions of the cerebral microvasculature are impaired in type 1 diabetes; and 1.2) To investigate to what extent the different functions of the cerebral microvasculature are…
Evaluate pharmacokinetic levels of imidazole propionate (ImP) as a result of orally administrated histidine and assess the role of the gut microbiota in this respect, in Type 2 diabetes (T2D) from Dutch and South Asian Surinamese descent as compared…
Objective: To collect a broad array of clinical, behavioural, physical and biochemical parameters, to ensure that many clinical research questions or problems related to successful aging with T1D can be answered. Nevertheless, we have a priori…
Objective: The aim of the present study is to study the effect of increased adrenaline levels on the inflammatory response (e.g. leukocyte phenotype, cytokines, inflammatory proteins) by administering exogenous adrenaline. Secondary aims consist of…
To investigate the effect of daily intake of 350 milligrams of magnesium citrate oral supplementation over a period of six months on calciprotein particle maturation time (T50) in serum, a measure of calcification propensity, and on vascular…
Metabolic effects of ketohexokinase inhibition in individuals with non-alcoholic fatty liver disease
Primary objective: determining the effect of the ketohexokinase inhibitor, PF-06835919, on hepatic insulin sensitivity in individuals with non-alcoholic fatty liver disease.Secondary objective: determining the effect of the ketohexokinase inhibitor…
The study investigates whether the glycemic response to standardized snacks differs within subjects between different times of the day. The study concerns a pilot for a future larger study of more complex aspects of the nutritional and physical…
The primary objective of this study is to validate 31P-MRS as a non-invasive in vivo measure of mitochondrial function. Secondary objectives are to determine whether there is mitochondrial dysfunction in the heart of type 2 diabetic patients and to…
Primary Objective: Gain insight in the course of plasma phosphate and its (de-)regulators during DKA. Secondary Objective(s): Address the potential association and role of hypophosphatemia in oxidative stress / mitochondrial dysfunction / tissue…
With this proof-of-concept study, we will address i. differences in dopamine release in T2DM patients versus historical lean controls, ii. whether timed restoring of dopamine signalling improves dopamine release and iii. whether this reinstatement…
Primary objective:* To investigate the consequences of (recurrent) hypoglycaemia on inflammatory responsesSecondary objectives:* To study the atherogenic consequences of (recurrent) hypoglycaemia* To study the molecular mechanisms involved in the…
The main objective of this study is to investigate if exercise training improves 24h rhythmicity in substrate metabolism in prediabetes subjects. Secondary objectives include linking 24h substrate metabolism to day-night differences in mitochondrial…
1. To establish optimized and standardized approaches for the isolation and characterization of BOECs in control and diabetic patients.2. To test whether the phenotype of BOECs cultured from blood of diabetic patients are significantly different…
To correlate platelet activity, PMV production and platelet and PMV RNA content to renal outcomes in diabetic nephropathy and to investigate the interaction between PMV and glomerular endothelial cells and podocytes.