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Eindhoven Long-term Diabetes Education Study

To investigate the cost-effectiveness and long-term effects on cardiovascular risk, quality of life and diabetes self-management behavior of the educational program *Beyond Good Intentions* in known type 2 diabetes patients.

Diabetic cardiovascular Autonomic Neuropathy in patients undergoing major abdominal and cardiothoracic Surgery

In this study we aim to investigate the presence of CAN in diabetic patients scheduled for elective major abdominal and thoracic surgery and its relation with perioperative hemodynamic changes.

the effect of felted foam on peak pressure relief and preservation in the feet of healthy individuals

The current research project will investigate the pressure relieving and preservation effects of felted foam. The aim of this study is to find the type of felted foam that is most effective in reducing plantar peak pressures. Furthermore, this study…

Butyrate Use in TYpe 1 diabetes: effects on Regulation of bActerial translocation, innate immunity, T-cell function and Endotoxemia

To investigate whether ingestion of 4 grams of butyrate daily during 4 weeks can positively affect the immune system function, residual betacell function and low grade inflammation in patients with type 1 diabetes mellitus.

Advanced glycation end products (AGE) measured by skin autofluorescence and the association with vascular compliance in children with type 1 diabetes.

The aim of this study is to investigate if changes in vascular compliance in children with type 1 diabetes are related to endothelial markers and to changes in skin AGE and to investigate whether patients at risk to develop cardiovascular disease…

Novel diagnostic test to improve cardiovascular disease risk reduction in subjects with type 2 diabetes, increasing cost effectiveness and quality of life.

The aim of this study is to answer the question: *Will the addition of the lipoprotein profile to the conventional diagnostics for dyslipidemia in T2D patients, lead to a better risk classification of CVD development?*. The improved risk…

Survey of Health, Ageing and Retirment in Europe (SHARE)

Including the collection of biological biomarkers into a social survey such as SHARE is of important scientific value as it opens up multiple research possibilities: -Identification of causal relationships: biological biomarkers can help to…

The effects of random vibrations on the vibratory perception threshold of the foot and standing balance in people with diabetic neuropathy

To investigate the effects of vibrating insoles on vibration perception threshold (VPT) and balance of people with diabetic neuropathy.

A study to assess the anti-albuminuric effects and variability in response to dapagliflozin in subjects with type 2 diabetes

Primary Objective: To assess the change from baseline in 24-hr albuminuria with dapagliflozin for six weeks relative to placebo treatment in patients with diabetes and albuminuria > 100 mg/day on stable ACEi or ARB treatment.Secondary…

The Innate Immune System in Atherosclerosis

The main objectives of this study is to see if changes in the innate immune system can be found in diseases associated with increased risk for atherosclerosis

The impact of the P4 approach, preventive, predictive, personalized and participatory, in prediabetic and newly diagnosed type 2 diabetics in Hillegom.

The main objective is to assess the impact of the P4 approach on established markers of glucose metabolism. Secondary objectives are changes in physical characteristics, questionnaires and the indices for beta cell function, hepatic insulin…

A phase 4, monocenter, randomized, open label, comparator-controlled, parallel-group, mechanistic intervention trial to assess the effect of 8-week treatment with the glucagon-like peptide-1 receptor agonist lixisenatide versus insulin glulisine on renal physiology and biomarkers in insulin glargine-treated patients with type 2 diabetes mellitus

Main study:Primary objective: What are the long-term effects (i.e. after 8-week drug exposure) of the GLP-1RA versus a single dose prandial insulin onrenal hemodynamics (glomerular filtration rate/ effective renal plasma flow in basal insulin-…

A Phase 2, Double-Blind, Randomized, Placebo Controlled Study to Evaluate the Efficacy and Safety of ASP8232 as Add-On Therapy to Angiotensin Converting Enzyme inhibitor (ACEi) or Angiotensin Receptor Blocker (ARB) in Reducing Albuminuria in Patients with Type 2 Diabetes and Chronic Kidney Disease.

Primary Objective:To evaluate the efficacy of ASP8232 in reducing Urinary Albumin Creatinine Ratio (UACR) in subjects with Type 2 Diabetes Mellitus (T2DM) and Chronic Kidney Disease (CKD) at 12 weeks compared to placebo.Secundary Objectives:1. To…

Biomarkers of microvascular function, circulating cells and endothelial integrity in kidney transplant recipients on belatacept or CNI

To disclose the pathofysiologic basis of the favourable risk profile by measuring factors associated with cardiovascular disease.

European phase-II clinical trial evaluating efficacy of low dose rhIL-2 in patients with recently diagnosed type 1 diabetes

Primary objective1. To evaluate efficacy of ILT-101 for the preservation of residual pancreatic β cells function2. To select the optimal regimen of administration of ILT-101.Secondary objectivesTo assess:1. Tregs expansion after an induction period…

Use of monomeric and oligomeric flavanols in the dietary management of patients with type 2 diabetes and microalbuminuria

The objective of this study is to determine whether monomeric and oligomeric flavanols have a beneficial effect on renal-endothelial function in the dietary management of T2D, as reflected by improvement of AER and renal-endothelial biomarkers