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Randomised, controlled, open label, cross-over trial to evaluate the tolerance of a new smoothie-style paediatric sip feed in children in need of oral nutritional support.

The primary objective of this study is to evaluate the tolerance of a new smoothie-style paediatric sip feed compared to a standard paediatric sip feed for a period of 6 weeks in children in need of oral nutritional support. The secondary objectives…

Feasibility study adjustable banded gastric bypass.

Testing the feasibility of adjustable gastric banding Roux- and Y gastric bypass in the Atrium Medical Center Parkstad

Normalcy of food intake in head and neck cancer patients receiving radiotherapy supported by swallowing therapy and individual dietary councelling.

To improve normalcy of food intake (food quantity and quality, decrease use of tube feeding/ nutritional supplements) in patients with head and neck cancer with pre-, per- and post treatment radiotherapy due to individually tailored swallowing…

PANFIRE - Pilot-study: Non-thermal ablation using Irreversible Electroporation (IRE) to treat locally advanced pancreatic carcinoma - a phase I clinical study

In this pilot-study we investigate the safety, feasibility and efficacy of IRE in locally advanced pancreatic carcinoma. We hypothesize that IRE of the pancreas is a safe treatment that will cause few complications. Moreover, we expect the treatment…

Setmelanotide (RM-493) Phase 2 Treatment Trial in Patients with rare genetic disorders of obesity

Main objective:To explore the impact of setmelanotide on obesity in patients with various specific rare genetic mutations.Secondary objective:To assess the effects of setmelanotide on:* Safety and tolerability-Hunger* Waist circumferenceOptional sub…

Changes in body composition during and after external beam radiotherapy for gynaecologic cancer

The primary objective of this study is to assess if clinically relevant changes occur in fat free mass (FFM) between baseline and follow up six months after the end of treatment. Our cut-off value of a clinically relevant difference in body…

A randomized controlled trial on the effect of pre-thickened oral nutritional supplements on nutritional status of nursing home residents with oropharyngeal dysphagia and (at risk of) malnutrition

The aim of this study is to determine whether the daily use of thickened oral nutritional supplements has an effect on the weight of nursing home residents with dysphagia and (risk for) malnutrition.