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The effect of orally applied encapsulated lipids in yoghurt on satiety and food intake: a randomized single-blind study with cross-over design

To explore the ability of encapsulation of orally applied lipids in a yoghurt snack to modify ad libitum food intake and satiety, without GI symptoms.

Protein and lifestyle intervention to preserve muscle mass in obese older type 2 diabetes patients - a 13-week randomised, controlled exploratory study with a 24-week follow-up period.

Primary: To investigate the effect on leg muscle mass in the test group compared to the control group in older obese type 2 diabetes patients after 13 weeks of interventionSecondary: - To investigate the effect on glycemic control in the test group…

A 20-week, double-blind, randomized, placebo-controlled, parallel-group trial to assess the safety and efficacy of HM11260C on body weight in obese subjects without diabetes

Primary objective• To assess the effect of HM11260C, in combination with a hypocaloric diet, on body weight over the 20 weeks from baseline in obese subjectsSecondary objectives• To assess the safety, tolerability, and immunogenicity of HM11260C, in…

Randomised controlled trial to evaluate tolerance, intake and safety of a new high-energy high-protein oral nutritional supplement in elderly subjects in need of oral nutritional support.

The primary objective of this study is to evaluate tolerance of a new high-energy high-protein oral nutritional supplement compared to a commercially available high-energy high-protein oral nutritional supplement in elderly subjects in need of oral…

Randomised, controlled, open label, cross-over trial to evaluate the tolerance of a new smoothie-style paediatric sip feed in children in need of oral nutritional support.

The primary objective of this study is to evaluate the tolerance of a new smoothie-style paediatric sip feed compared to a standard paediatric sip feed for a period of 6 weeks in children in need of oral nutritional support. The secondary objectives…

Feasibility study adjustable banded gastric bypass.

Testing the feasibility of adjustable gastric banding Roux- and Y gastric bypass in the Atrium Medical Center Parkstad

Normalcy of food intake in head and neck cancer patients receiving radiotherapy supported by swallowing therapy and individual dietary councelling.

To improve normalcy of food intake (food quantity and quality, decrease use of tube feeding/ nutritional supplements) in patients with head and neck cancer with pre-, per- and post treatment radiotherapy due to individually tailored swallowing…

A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Dose Ranging Study to Investigate the Safety and Efficacy of JNJ-16269110 in Overweight and Obese Subjects

The primary objective of the study is to find the appropriate, clinically relevant dosages (among the 5, 10, and 15 mg twice-daily dosages) of JNJ-16269110 by assessing mean changes in body weight from baseline to Week 12, compared to placebo .The…

Protein intake, gastro-Intestinal tolerance and safety after administration of a new high protein tube feed in critically ill overweight ICU patients as compared to an isocaloric standard tube feed.

As meeting protein requirements seems to be very important in critically ill patients, the primary objective of the current study is to investigate protein intake with the new tube feed.

PANFIRE - Pilot-study: Non-thermal ablation using Irreversible Electroporation (IRE) to treat locally advanced pancreatic carcinoma - a phase I clinical study

In this pilot-study we investigate the safety, feasibility and efficacy of IRE in locally advanced pancreatic carcinoma. We hypothesize that IRE of the pancreas is a safe treatment that will cause few complications. Moreover, we expect the treatment…

A Phase 2b/3 study to evaluate the safety, tolerability, and effects of livoletide (AZP-531), an unacylated ghrelin analog, on food-related behaviors in patients with Prader-Willi syndrome

This Phase 2b/3 double-blind, placebo-controlled study will evaluate the safety, tolerability, and effects of livoletide on food-related behaviors in patients with Prader-Willi Syndrome (PWS).

Setmelanotide (RM-493) Phase 2 Treatment Trial in Patients with rare genetic disorders of obesity

Main objective:To explore the impact of setmelanotide on obesity in patients with various specific rare genetic mutations.Secondary objective:To assess the effects of setmelanotide on:* Safety and tolerability-Hunger* Waist circumferenceOptional sub…

A randomized controlled trial on the effect of pre-thickened oral nutritional supplements on nutritional status of nursing home residents with oropharyngeal dysphagia and (at risk of) malnutrition

The aim of this study is to determine whether the daily use of thickened oral nutritional supplements has an effect on the weight of nursing home residents with dysphagia and (risk for) malnutrition.

A Phase II, randomized, double blind, parallel group,46 weeks dose-finding study of BI 456906 administered once weekly subcutaneously compared with placebo in patients with obesity or overweight

The overall purpose of this trial is to assess the efficacy on weight loss and maintenance, and tolerability of four different doses of BI 456906 compared to placebo in patients with obesity or overweight (BMI >= 27kg/m2), without type 1 or…

Changes in body composition during and after external beam radiotherapy for gynaecologic cancer

The primary objective of this study is to assess if clinically relevant changes occur in fat free mass (FFM) between baseline and follow up six months after the end of treatment. Our cut-off value of a clinically relevant difference in body…