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Protein and lifestyle intervention to preserve muscle mass in obese older type 2 diabetes patients - a 13-week randomised, controlled exploratory study with a 24-week follow-up period.

Primary: To investigate the effect on leg muscle mass in the test group compared to the control group in older obese type 2 diabetes patients after 13 weeks of interventionSecondary: - To investigate the effect on glycemic control in the test group…

Enteral versus parenteral feeding in adult stem cell transplantation patients with chemotherapy-induced gastro-intestinal mucositis.

In this study, we will test which of two feeding strategies for adults during chemotherapy-induced mucositis is optimal with regards to maintaining an optimal body weight, nutritional status, gut mucosal barrier and treatment outcome (including…

*Omega-3 fatty acids in bariatric gastric bypass surgery: effects on liver volume, immune response and erythrocyte function*

Our primary objective is to compare pre-treatment with the standard low calorie diet with pre-treatment with supplemental omega-3 fatty acids on liver volume. Secondary objectives are patient satisfaction about different dietary pre-treatments, the…

A double blind, placebo controlled, randomized, cross-over study to assess the effects of polydextrose on appetite suppression and its mechanisms of action in healthy women with a normal weight and overweight female participants

The main objective is to evaluate the appetite suppressive effect of polydextrose, measured as the Energy Intake at ad libitum lunch (T=240 min) on normal weight and overweight women consuming 12.5 g of polydextrose or placebo in a low-fat yogurt as…

A 20-week, double-blind, randomized, placebo-controlled, parallel-group trial to assess the safety and efficacy of HM11260C on body weight in obese subjects without diabetes

Primary objective• To assess the effect of HM11260C, in combination with a hypocaloric diet, on body weight over the 20 weeks from baseline in obese subjectsSecondary objectives• To assess the safety, tolerability, and immunogenicity of HM11260C, in…

The effect of repetitive ileal brake activation on food intake, satiety, gastrointestinal peptide release, gastric emptying and gallbladder volume

Aim: To determine the effect of repetitive ileal brake activation on food intake, satiety, gastrointestinal peptide release (CCK, GLP-1, PYY, glucose and insulin) and gut motilityHypothesis: We hypothesize that after repetitive ileal infusion of…

The effect of intestinal brake activation at different locations in the gut on food intake and hormone release

Study A:Aim: To investigate the location specific differences (duodenum, jejunum and ileum) of casein infusion on ad libitum food intake, satiety scores and the release of gastrointestinal peptides , associated with food intake and satiety (CCK, GLP…

Behavioral and physiological responses to sensory-specific satiety

To investigate responses of the autonomic nervous system (ANS) and facial expressions to sensory-specific satiety.

Active Care After Transplantation: ACT for the future

The proposed randomized controlled lifestyle intervention studies the effects of an exercise and nutrition intervention in the first year after transplantation on: 1. Exercise capacity, muscle strength, diet, quality of life and social participation…

Program sustainable vitality

This study aims to evaluate the efficacy of an extensive eSupported lifestyle program in reducing physical risk factors.

Dysphagia in children with congenital myopathy, underlying mechanisms and advices for assessment and treatment

Objective 1To describe the course and underlying mechanisms of dysphagia in children with congenital myopathy (from 6 months to 12 years)Objective 2To formulate recommendations for early detection, diagnostic assessment , treatment and advices for…