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Interindividual variability in brain vulnerability to elevated blood phenylalanine concentrations in PKU patients - pilot study on amino acid transport in fibroblasts as a representative of the blood-brain barrier

To further characterize the transport of phenylalanine and other large neutral amino acids across the blood-brain barrier in PKU patients with high and low brain vulnerability to elevated blood phenylalanine concentrations, we will investigate…

Evaluation of plasma chitotriosidase, plasma cytokines and cystine crystal scoring in skin and hair for the non-invasive therapeutic monitoring of nephropathic cystinosis.

Based on this background information and our preliminary data in this project we aim to perform longitudinal study in cystinosis patients to correlate clinical course under cysteamine therapy and 1) Markers of macrophage activation in patients…

The influence of different levels of protein diet on protein oxidation measured by 13CO2 breath test

The aim of this study is to determine whether our 13CO2 breath test is discriminative for different protein diets in healthy young volunteers.

The influence of different levels of exercise on protein oxidation measured by 13CO2 breath test

To test whether our breath test differentiates between a baseline state and two different levels of exercise (15 minutes at 30% of VO2 max and 15 minutes at 60% of VO2 max) in 16 healthy volunteers, thereby confirming or denying that protein…

Protein oxidation in stable renal transplant patients measured with a breath test

To study whether stable renal transplant patients show higher protein oxidation measured with the 13C-breath test as compared to healthy kidney donor subjects.