17 results
To further characterize the transport of phenylalanine and other large neutral amino acids across the blood-brain barrier in PKU patients with high and low brain vulnerability to elevated blood phenylalanine concentrations, we will investigate…
The primary objective of this study is to investigate the effect of different levels of oral phenylalanine supplementation on the blood concentration and diurnal variation of phenylalanine and tyrosine in HT1 patients treated with NTBC. This in…
To evaluate the safety, tolerability, protein accretion, amino acid plasma levels and long-term outcome of Neoven compared to Vaminolact in preterm infants with a birth weight from 800 g to less than 1500 g and with a gestational age from 25 weeks…
1) To assess insulin sensitivity and response in critically ill septic neonates and children. 2) To determine protein balance in septic, critically ill children at baseline and during a Hyperinsulinemic Euglycemic Clamp, while receiving standard or…
A reduction of the fasting period may prevent or reduce the rise in plasma Phe concentration. Therefore, the aim of the study is to measure the effect of the application of slow releasing carbohydrates (SRC) as evening meal before bedtime on the…
Overall Objective: To define the properties of whey, casein, milk protein, as well as soy protein with and without additional leucine to augment post-exercise muscle protein synthesis when co-ingested with a carbohydrate containing recovery drink.…
To define a dose-response relationship after intrinsically labeled milk protein ingestion on myofibrillar and mitochondrial muscle protein synthesis after a single bout of endurance exercise.
Based on this background information and our preliminary data in this project we aim to perform longitudinal study in cystinosis patients to correlate clinical course under cysteamine therapy and 1) Markers of macrophage activation in patients…
The influence of different levels of protein diet on protein oxidation measured by 13CO2 breath test
The aim of this study is to determine whether our 13CO2 breath test is discriminative for different protein diets in healthy young volunteers.
Primary:• To evaluate the efficacy of PTC923 in reducing blood phenylalanine (Phe) levels in subjects with phenylketonuria (PKU) as measured by mean change in blood Phe levels from baseline to Weeks 5 and 6 (ie, the average of each respective…
This study has been transitioned to CTIS with ID 2023-509229-31-00 check the CTIS register for the current data. Primary:• To evaluate the long-term safety of PTC923 in subjects with phenylketonuria (PKU)• To evaluate changes from baseline in…
To assess the postprandial incorporation of dietary protein derived amino acids in intestinal epithelium in healthy young and older males.
To assess the effects of aging on protein digestion and amino acid absorption in healthy humans.
Evaluation of a novel alternative protein source to stimulate post-exercise muscle protein synthesis
From p11 of C1 protocol document:1) To define the characteristics of mealworm protein ingestion on protein/digestion absorption kinetics and both whole-body and myofibrillar muscle protein synthesis after a single bout of resistance exercise in…
To test whether our breath test differentiates between a baseline state and two different levels of exercise (15 minutes at 30% of VO2 max and 15 minutes at 60% of VO2 max) in 16 healthy volunteers, thereby confirming or denying that protein…
Primary Objectives:1. Determine the impact of short-term (3 days) unilateral lower-limb immobilization on *cumulative* rates of MPS in younger and older adults.2. Determine whether leucine supplementation can prevent declines in cumulative MPS and…
To study whether stable renal transplant patients show higher protein oxidation measured with the 13C-breath test as compared to healthy kidney donor subjects.