75 results
The main aim of the EuroFIT trial is to assess the effectiveness and cost-effectiveness of the EuroFIT programme in supporting men to achieve an increase of at least 1000 steps per day (about 10 minutes on average per day, or 70 minutes per week)…
The purpose of this study is to evaluate whether thyroid hormone replacement therapy in type 2 diabetic patients suffering from overt hypothyroidism will improve muscular mitochondrial function, lower ectopic fat accumulation in muscle and liver,…
Primary Objectives: - DirectLifeDirectLifeAre the LiveWorkout® and DirectLife® concept feasible web based training programs for type 2 diabetes patients ?- How do type 2 diabetes patients experience web based training intervention programs ? What…
The primary objective of this study is to investigate the differences in metabolic flexibility after high and low dairy intake for 6 weeks. Glucose kinetics and insulin sensitivity (dual isotope technique), as well as metabolic responses (glucose,…
The primary aim of the present research is to determine if a digital health program, with information about nutrition/physical activity/diabetes and feedback on physical activity behaviour by an activity tracker leads to improvement of glycemic…
The purpose of the present study is to test whether a structured Bolus Calculation education program and subsequent use of the Accu-Chek® Aviva Expert blood glucose meter with an integrated bolus advisor can improve glycemic control in diabetes…
The overall objective of this study is to increase the uptake and maintenance of healthy behaviors among adults from non-Western immigrant populations who are identified as having a high risk of cardiometabolic disease after completing a health…
In addition to our current research in type 2 diabetes patients on oral blood glucose lowering medication, we would like to assess the glucoregulatory effects of different exercise modalities in the impaired glucose tolerant (pre-diabetes) state and…
The effect of radiotherapy on glucose metabolism in patients with rectal cancer; a feasibility study
Primary objective:Effect of preoperative radiotherapy on insulin resistance in rectal cancer patients.Secondary objectives:Effect of preoperative radiotherapy on plasma oxidative stress parameters.
The primary objective of this study is to investigate whether skeletal muscle glucose metabolism, perioperative glucose control and hemodynamics are affected by increasing physical activity in the weeks preceding surgery in patients identified with…
The effect of NEAT or inactivity on insulin sensitivity and lipid metabolism is unclear. The objective of the present study is to evaluate the effect of 4 days of mainly sitting, or sitting and walking, or sitting, walking and biking on glucose and…
The objective of the study is to estimate the prevalence of (abdominal) overweight/obesitas, metabolic syndrome (and its components), and undiagnosed diabetes in the Dutch population, aged 30-69 years. Besides, differences in lifestyle (smoking and…
Our aim is to compare the effect of 8-week exercise training and exercise training under hypoxia on vascular adaptations in function and structure, but also metabolic control (insulin resistance)
The objective of the study is to investigate effects of training on insulin resistance (IR), chronic heart failure (CHF) and cognition of resthome residents.
The overall aim of the DALI study is to identify the best available measures to prevent GDM in an ongoing pregnancy, to provide a cost-benefit calculation of GDM prevention for health care systems, and to establish a pan-European cohort of mother-…
The current research proposal aims to investigate the medium and long-term health benefits of a combined supervised exercise and dietary intervention versus a dietary intervention (=usual care) in obese long-standing type 2 diabetes patients. It is…
Are AGEs, as a predictor of increased risk for cardiometabolic syndrome, increased in shift workers?
The aim of this study is to investigate skin AGEs, as a predictor of increased risk for cardiometabolic syndrome, in a shift work population as compared to non-shift workers to assess its potential as an early assessment of the actual risk for…
We will examine the feasibility of an experimental condition- in which either a passive or active school morning is simulated- to test the effect of physical activity on cognition and cardiovascular health in children. In addition, we will gather…
Primary objective: To investigate whether butyrate influences the metabolic activity of BAT (as assessed with a FDG-PET CT scan) in relation to hepatic and peripheral insulin sensitivity (2H2-glucose and [1,1,2,3,3-2H5]glycerol based two step…
The main objective is to explore the effects of a 10-day fasting and exercise program on body composition and physical performance (peak power, endurance capacity, efficiency and resting VO2¬) of overweight, fit men and compare these effects with…