18 results
The primary objectives are to investigate whether L-carnitine infusion may rescue lipid-induced insulin resistance and whether L-carnitine infusion is improving metabolic flexibility in the state of lipid-induced insulin resistance. Furthermore,…
Not applicable
The primary objective of the study is to investigate whether local insulin supplementation augments the in vivo postprandial muscle protein synthetic response after protein ingestion and whether this response is differs between young and elderly…
Objective: To study differences of (adipo) cytokine spectra in visceral and peripheral adipose tissue and to study the effect of caloric restriction on (adipo) cytokine production of these different fat tissues.
Primary ObjectiveTo determine whether moderate alcohol consumption influences subsequent food reward, as measured by questionnaires on food *wanting* and food *liking*, and salivary and blood parameters related to food reward.Secondary ObjectivesTo…
To characterize the glycaemic and insulinaemic responses of regular camel milk and camel milk powder in healthy adults.
This project consists of two related studies. The objective of part 1 is to investigate the effect of elevated plasma lactate levels that are sufficient to impair awareness of hypoglycemia on brain lactate concentrations during euglycemia and…
1. The primary aim of the study is to investigate whether periodontal treatment results in a decrease of plasma biomarkers that are related to cardiovascular diseases (CVD) and metabolic syndrome (MS) and what is the effect of the treatment on the…
Does bilateral deep brain stimulation of the subthalamic nucleus in patients with Parkinson's disease influence plasma triglycerides and glucose metabolism?
The goal of this study is examining the acute effects of insulin on microcirculation in hypertensive insulinresistant subjects and investigate if angiotensine II influences these effects. Amendement: The goal of the amendement is to exame the…
To investigate whether single dosis of fecal therapy by infusion of allogeneic (post bariatric surgery donor feces in the bowel) or autologous (own feces) have differential effect on lipid-metabolism-mediated insulin resistance.
Objective of the study:1) To assess insulin sensitivity and response in critically ill septic neonates and children.2) To determine protein balance in septic, critically ill children at baseline and during a HyperinsulinemicEuglycemic Clamp, while…
We hypothesize that improving sleep will improve glycaemic control in people with T2DM and insomnia. To test this hypothesis, we established the following objectives: 1) investigate if improving sleep by internet-based cognitive behavioural therapy…
To study the effect of WF Fiber on insulin resistance and (continuous) glucose metabolism and potential underlying mechanisms, body weight and waist circumference, microbiota composition and fasting GLP1/PYY/SCFA, in subjects with pre-diabetes.
To investigate the effect of intravenous lactate administration, compared to placebo, on thalamic (regional) and global CBF during euglycemia and hypoglycemia in patients with T1DM and NAH.
We intend to perform a pilot study to determine the optimal nutrient mix (predominantly based on medium-chain triglycerides, MCTs) to induce a mild ketogenic state in healthy older (60-80y), overweight/obese (BMI: 25-35 kg/m2). Since the aim is to…
To evaluate the effect of a LiPA intervention on arterial stiffness in individuals with T2D.
To examine the effect of adrenergic inhibition on the hypoglycaemia induced inflammatory response (e.g. leukocyte phenotype, cytokines, inflammatory proteins) by performing a hyperinsulinaemic hypoglycaemic glucose clamp alongside infusion of α-ARA…