48 results
In this double blinded randomised controlled trial we aim to compare the effects of 4 grams of oral butyrate tablets once daily following autologous (own) faecal transplantation with post-RYBG donor faecal transplantation with placebo tablets, at…
to investigate whether microbial transplantation from either allogenic (healthy) or autologous (own) donor, administered through a small intestinal tube, has beneficial effects on immune status, betacell function c-peptide secretion upon mixed meal…
To test the hypothesis that metabolic inflexibility in pre-diabetic subjects and diabetic patients is due to a reduced capacity to form acetylcarnitines: We aim to investigate whether glucose intolerant subjects have a lower capacity to form acetyl-…
The purpose of the study is to investigate wether long-term resveratrol supplementation (6 months) leads to improved insulin sensitivity (estimated by Matsuda Index) in people with overweight/obesity. In addition we will investigate effects of…
PrimaryThe 3 months* effect of Vildagliptin on insulin synthesis and storage capacitySecondaryThe 3 months* effect of vildagliptin on- Glucose, insulin, C-peptide levels- Hormonal axes, most importantly GLP1 and GIP and Glucagon- Body weight, body…
To explore the inflammatory changes of a PCSK-9 inhibitor compared with placebo on postprandial lipemia and postprandial leukocyte activation, oxidative stress and endothelial function in men with type 2 diabetes mellitus.
To investigate whether increased aldosterone levels in obese individuals lead to impairment of microvascular function through reduction of NO-availability, and to establish the role of microvasculaire dysfunction in the pathogenesis of salt-…
Based on our hypothesis that orally administered GOS will be fermented into a SCFA pattern high in acetate and that this will lead to beneficial effects on human substrate and energy metabolism, we aim to address the following primary objective: To…
In this follow-up study we would like to compare the effect of single versus multiple (2x) duodenenal tube infused allogenic versus autologous feces (as controls) on insulin resistance, cholesterol and (shortchain) free fatty acid metabolism in…
The primary objective of the study is to investigate whether carbohydrate co-ingestion augments the in vivo postprandial muscle protein synthetic response after protein ingestion and whether this response is differs between young and elderly…
To provide insight in the physiological significance and underlying mechanisms involved in the relation between gut microbiota, energy balance and insulin sensitivity in overweight men with impaired glucose homeostasis
Our primary objective is the effect of taurine on morbidity and consequent mortality.
To examine whether resveratrol supplementation in type 2 diabetic patients improves overall and muscle-specific insulin sensitivity by affecting mitochondrial fat oxidative capacity. Furthermore, we are interested is this also affects liver and…
To investigate whether the in vivo postprandial muscle protein synthetic response is augmented when dietary nitrate ingestion precedes protein ingestion in elderly type 2 diabetics.
Based on our hypothesis that differential availability of SCFA will be beneficial effects on substrate and energymetabolism, the following objectives have been and will be addressed:- In our previous study (METC 11-3-079, NL38679.068.11) we have…
Based on our hypothesis that orally ingested inulin is fermented into different SCFAs, and these SCFAs can have beneficial metabolic effects, we aim to address the following primary objective: To investigate the human metabolic effects of SCFA…
The aim of this study is to investigate the effect of different doses of vitamin D on postprandial leukocyte activation markers, oxidative stress and arterial stiffness in vitamin D deficient females.
Based on our hypothesis that differential availability of SCFA will have beneficial effects on substrate and energy metabolism, the following objectives will be addressed:In this pilot study we will validate whether rectal administration of SCFA is…
The primary objective of the present study is to investigate the postprandial effect of arginine-rich protein (i.e. pea-protein) on metabolic control, inflammation and endothelial function after a high-fat meal in subjects with the metabolic…
Main study:1. Does blockade of the angiotensin II AT1-receptor improve the insulin-induced microvascular effects in hypertensive patients.2. Does blockade of the angiotensin II AT1-receptor impair the insulin-induced mi-crovascular effects in…